Boron neutron capture therapy using pre-targeting methods

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 137, 424 153, 4241551, 435 723, 5303888, 53038885, G01N 3353

Patent

active

058467416

ABSTRACT:
The present invention provides a method for targeting boron atoms to tumor cells in a patient. The method comprises the steps of:

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4624846 (1986-11-01), Goldenberg
patent: 4732863 (1988-03-01), Tomasi et al.
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 5443813 (1995-08-01), Hainfeld
patent: 5462724 (1995-10-01), Schinazi et al.
patent: 5482698 (1996-01-01), Griffiths
patent: 5525338 (1996-06-01), Goldenberg
patent: 5612017 (1997-03-01), Miura et al.
Mehta et al., "Targeted Drug Delivery for Boron Neutron Capture Therapy", Parmaceutical Research, vol. 13, No. 3, pp. 344-351 (1996).
Sinitsyn, et al. "Use of Avidin for Enhanced Blood Clearance of Biotinylated Immunoglobulins," Byull. Eksp. Biol. Med., 109:6 pp. 567-569 Russian with English/ abstract (1990).
Paganelli, et al. "Tumor Targeting in Patients with Ovarian Cancer Using Biotinylated Monoclonal Antibodies and Radioactive Streptavidin," J. Nucl. Med., 31:5 p. 735 (May 1990), Abstract No. 117.
Hnatowich, et al. "Investigations of Avidin and Biotin for Imaging Applications," J. Nucl. Med., 28:8 pp. 1294-1302 (1987).
Paganelli, et al. "Three-Step Monoclonal Antibody Tumor Targeting in Carcinoembryonic Antigen-positive Patients," Cancer Res., 51:21 pp. 5960-5966 (Nov. 1991).
Kalofonos, et al. "Imaging of Tumor Patients with Indium-111-Labeled Biotin and Streptavidin-Conjugated Antibodies: Preliminary Communications," J. Nucl. Med., 31:11 pp. 1791-1796 (Nov. 1990).
Fuccillo, D.A. "Application of the Avidin-Biotin Technique in Microbiology," Bio Techniques 3:5 pp. 494-501 (1985).
Ferro et al. "Antibody Targeting of Boron Compounds" :Proceedings of the Fourth International Symposium on Neutron Capture Therapy for Cancer Held Dec. 4-7, 1990 in Progress in Neutron Capture Therapy/for Cancer, Plenum Press, New York, pp. 269-271, 1992.
Holmberg et al., "Preparation of Sulfhydrylborane-Dextran Conjugates for Boron Neutron Capture Therapy," Bioconjugate Chemistry, 4 (1993) 570-3.
Komura et al., "Thermal Neutron Capture Therapy of Malignant Melanoma Using .sup.10 B-Monoclonal Antibodies: in vitro and in vivo Analysis," Melanoma Research, 1 (1991): 397-403.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Boron neutron capture therapy using pre-targeting methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Boron neutron capture therapy using pre-targeting methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Boron neutron capture therapy using pre-targeting methods will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-175931

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.