Boron-gadolinium compounds and method of conducting imaging and/

Details Boron-gadolinium compounds and method of conducting imaging and/ Boron-gadolinium compounds and method of conducting imaging and/

1992-09-11

1994-02-15

Stoll, Robert L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Rare earth containing

C07F 502

Patent

active

052868532

ABSTRACT:
A gadolinium (3.sup.+) complex of polyamine polyacetate, comprising a polyamine nucleus having a pendant boron-containing substituent on one of the nitrogen or carbon atoms of the polyamine nucleus. The boron-gadolinium compound may suitably be of the formula: ##STR1## wherein: is a polyamine coordination structure capable of covalently bonding the substitutents R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and of complexing with Gd;

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Brugger, et al., "Evaluation of Gd-157 As a Neutron Capture Therapy Agent" Strahlenther Onkol. 165 (1989), 153-156.
Dischino, et al., "Synthesis of Nonionic Gd Chelates Useful as Contrast Agents for MRI", Inorg Chem 30 (1991), 1265-1269.
Takagaki Masao, et al, "Gadolinium Neutron Capture Therapy for Brain Tumors--Biological Aspects," Springer-Verlag, Tokyo, 1991, pp. 494-499.
Shih, J. A., et al. "Progress in Neutron Capture Therapy for Cancer" (Allen, B. J., et al, eds.) Plenum Press, New York, 1992, pp. 183-186.
Allen, B. J., et al "Neutron Capture Therapy With Gadolinium-157," Strahlenther. Onkol. 165 (1989), 156-157 (No. 2/3).

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