Boron difluoride compounds useful in photodynamic therapy and pr

Details Boron difluoride compounds useful in photodynamic therapy and pr Boron difluoride compounds useful in photodynamic therapy and pr

1993-02-19

1995-08-29

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548110, 548405, C07F 502

Patent

active

054461570

ABSTRACT:
A new group of fluorescent organic compounds having a variety of uses are described. They are especially useful as dye compounds in dye laser systems, and as photochemical agents in the treatment of diseased tissues using photodynamic therapy techniques. The compounds include a tri-cyclic compound having the following structure: ##STR1## Preferably R.sub.1 -R.sub.5 .dbd.R.sub.9 -R.sub.12 .dbd.C; R.sub.7 .dbd.B; R.sub.6 and R.sub.8 .dbd.N; R.sub.14 .dbd.lower n-alkyl or an electron withdrawing group such as CN.sup.- ; R.sub.16 and R.sub.19 are independently selected from the group consisting of lower n-alkyl, a sulfate or an acid or salt thereof, or hydrogen; and R.sub.20 .dbd.R.sub.21 .dbd.F. Other compounds include compounds of the formula ##STR2##

REFERENCES:
patent: 4774339 (1988-09-01), Haugland et al.
patent: 4799230 (1989-01-01), Boyer
patent: 5187288 (1993-02-01), Kang et al.
patent: 5248782 (1993-09-01), Haugland et al.
patent: 5274113 (1993-12-01), Kang et al.
patent: 5338854 (1994-08-01), Kang et al.
Triebs et al, Chemical Abstracts, vol. 70 (1969) 37589u.
Falk et al, Chemical Abstracts, vol. 92 (1980) 75389s.
Wories, H. J., "A Novel Water-Soluble Fluorescent Probe: Synthesis, Luminescence, and Biological Properties of the Sodium Salt of the 3,3',5,5'-tetramethyl-2,2'-pyrromethene-1,1'-BF.sup.2 Complex", Recueil Des. Travaus Chemiques des Pays-Bas, 104/11, (Nov. 1985), pp. 288-291.
Pavlopoulos, Theodore G.; Sha, Mayur and Boyer, Joseph H., "Laser Action From a Tetramethylpyrromethene-BF.sup.2 Complex" Applied Optics, vol. 27, No. 24, pp. 4998-4999 (Dec. 1988).
E. Vos de Wael, et al., "Pyrromethene-BF.sub.2 complexes (4,4'-difluoro-4-bora-3a,4a-diaza-s-indacenes). Synthesis and luminescence properties", J. of the Royal Netherlands Chemical Society, 96:306-309 (1977).
Chemical Abstracts 111:47646r (1989), "Efficient laser action from 1,3,5,7,8-pentamethyl-pyrromethene-boron difluoride complex and its disodium 2,6-disulfonate derivative."
Chemical Abstracts 111:123190e (1989), "Quasiaromatic heterocyclics as laser dyes."
Basting et al., "New Laser Dyes," App. Phys. 3:81-88 (1976).
American Association for Cancer Research Abstract 30:576 (1989) #2292.

Affiliated with

Also associated with

Rating

Boron difluoride compounds useful in photodynamic therapy and pr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Boron difluoride compounds useful in photodynamic therapy and pr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Boron difluoride compounds useful in photodynamic therapy and pr will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1820295