Boron-containing porphyrin compounds and their uses

Details Boron-containing porphyrin compounds and their uses Boron-containing porphyrin compounds and their uses

2006-10-25

2011-12-06

Ward, Paul V. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08071760

ABSTRACT:
Boron-containing porphyrin compounds are disclosed that may be used for boron neutron capture therapy of tumors, radiotherapy of tumors, and photodynamic therapy of tumors.

REFERENCES:
patent: 4959356 (1990-09-01), Miura et al.
patent: 2005/0124596 (2005-06-01), Zhang et al.
patent: WO 01/85736 (2001-11-01), None
Barth, R. et al., “Boron Neutron Capture Therapy of Cancer: Current Status and Future Prospects,”Clin. Canc. Res., vol. 11, No. 11, pp. 3987-4002 (2005).
Barth, R., “Boron Neutron Capture Therapy for Cancer,”Cancer, vol. 70, pp. 2995-3007 (1992).
Barth, R. F. et al., “Boron Neutron Capture Therapy of Brain Tumors: An Emerging Therapeutic Modality,”Neurosurg., vol. 44, No. 3, pp. 433-451 (1999).
Bobadova-Parvanova, P. et al., “Ab initioand1H-NMR Study of the Zn(II) Complexes of anido- and acloso-Carboranylporphyrin,”Journal of Porphyrins and Phthalocyanines, vol. 8, pp. 996-1006 (2004).
Bonnett, R., “Photosensitizers of the Porphyrin and Phthalocyanine Series for Photodynamic Therapy,” Chem. Soc. Rev.,vol. 24, pp. 19-33 (1995.
Chayer, S. et al., “Syntheses of Carboranylpyrroles,”Tetrahedron Letters, vol. 42, pp. 7759-7761 (2001).
Clark, J. C. et al., “Novel Carboranylporphyrins for Application in Boron Neutron Capture Therapy (BNCT) of Tumors,”Tetrahedron Letters, vol. 46, pp. 2365-2368 (2005).
Clark, J. C. et al., Syntheses and Properties of Carboranylpyrroles.Journal of Porphyrins and Phthalocyanines, vol. 9, 803-810 (2005).
Dougherty, T. J. et al., “Photodynamic Therapy,”Natl. Cancer Inst., 1998, vol. 90, 889-905 (1998).
Elowitz, E. H. et al., “Biodistribution ofp-Boronophenylalanine in Patients with Glioblastoma Multiforme for Use in Boron Neutron Capture Therapy,”Neurosurgery, vol. 42, No. 3, pp. 463-469. (1998).
Fabre, B. et al., “First conducting Polymer Functionalized with Covalently Linked Carborane Units,”Electrochemistry Communications, vol. 5, pp. 431-434 (2003).
Fabre, B. et al., Synthesis and Electrochemistry of Carboranylpyrroles. Toward the Preparation of Electrochemically and Thermally Resistant Conjugated Polymers.Macromolecules, vol. 39. pp. 112-119 (2006).
Gottumukkala, V. et al., “Synthesis and Cellular Studies of an Octa-anionic 5,10,15,20-Tetra[3,5- (nido-carboranylmethyl)phenyl]porphyrin (H2OCP) for Application in BNCT,”Bioorganic and Medicinal Chemistry, vol. 13, pp. 1633-1640 (2005).
Gottumukkala, V. et al., “Synthesis, Cellular Uptake and Animal Toxicity of a Tetra(carboranylphenyl)-tetrabenzoporphyrin,”Biorganic and Medicinal Chemistry, vol. 14, pp. 1871-1879 (2006).
Hao, E. et al., “Expeditious Synthesis of Porphyrin-cobaltacarborane Conjugates,”Chemical Communications, pp. 1306-1308 (2005).
Hao, E. et al., “Synthesis of Oxacalixarene-Locked Bisporphyrins and Higher Oligomers,”Journal of Organic Chemistry, vol. 71, 1233-1236 (2006).
Hao, E. et al., “Synthesis and Cellular Studies of Porphyrin-Cobaltacarborane Conjugates,”Bioconjugate Chemistry, vol. 16, 1495-1502 (2005).
Hawthorne, M. F., “New Horizons for Therapy Based on the Boron Neutron Capture Reaction,”Mol. Med. Today, vol. 4, pp. 174-181 (199, (1994).
Hawthorne, M. F. “The Role of Chemistry in the Development of Boron Neutron Capture Therapy of Cancer,”Angew. Chem. Int. Ed. Engl., vol. 32, 950-984 (1993).
Kageji, T. et al., “Pharmacokinetics and Boron Uptake of BSH (Na2B12H11SH) in Patients With Intracranial Tumors,”Neurooncol., vol. 33, pp. 117-130 (1997).
Kawabata, S. et al., “Evaluation of Carboranylporphyrins as Potential Delivery Agents for Neutron Capture Therapy of Brain Tumors,” Proc Amer Assoc Cancer Res, vol. 46, p. 4754 (2005).
Kawabata, S. et al., “Evaluation of Carboranylporphyrins as Boron Delivery Agents for Neutron Capture Therapy,”Proceedings for the 12th International Symposium on Neutron Capture Therapy for Cancer, pp. 123-126 (2006).
Kawabata, S. et al., “Evaluation of the Carboranyl porphyrin H2TCP as a Delivery Agent for Boron Neutron Capture Therapy (BNCT),”Proceedings of the 13th World Congress of Neurological Surgery, pp. 975-979 (2005).
Lauceri, R. et al., “Interactions of Anionic Carboranylated Porphyrins with DNA,”J. Am. Chem. Soc., vol. 123, pp. 5835-5836 (2001).
Luguya, R. et al., “Synthesis and Cellular Studies of a Carboranylchlorin for the PDT and BNCT of Tumors,”Bioorganic and Medicinal Chemistry, vol. 14, pp. 5890-5897 (2006).
Luguya, R. et al., “Synthesis and Reactions ofmeso-(p-Nitrophenyl)porphyrins,”Tetrahedron, vol. 60, pp. 2757-2763 (2004).
Luguya, R. et al., “Synthesis of Novel Carboranylchlorins with Dual Application in Boron Neutron Capture Therapy (BNCT) and Photodynamic Therapy (PDT),”Journal of Applied Radiation and Isotopes, vol. 61, pp. 1117-1123 (2004).
Luguya, R.J. et al., “Carboranylcorroles,”Tetrahedron Letters, vol. 46, pp. 5365-5368 (2005).
Luo, Y. et al., “Initiation of Apoptosis versus Necrosis by Photodynamic Therapy with Chloroaluminum Phthalocyanine,”Photochem. Photobiol, vol. 66, No. 4, pp. 479-483 (1997).
Maderna, A. et al., “Synthesis of a porphyrin-labelled carboranyl phosphate diester: a potential new drug for boron neutron capture therapy of cancer,” Chem. Commun., pp. 1784-1785 (2002).
Ongayi, O. et al., “Synthesis and Characterization of a Carboranyl-tetrabenzoporphyrin,”Bioorganic and Medicinal Chemistry Letters, vol. 15, pp. 1665-1668 (2005).
Pignol, J.-P. et al., “Selective Delivery of10B to Soft Tissue Sarcoma Using10B-L-borophenylalanine for Boron Neutron Capture Therapy,”Br. J. Radiol., vol. 71, pp. 320-323 (1998).
Renner, M.W. et al., “Recent Progress in the Syntheses and Biological Evaluation of Boronated Porphyrins for Boron Neutron-Capture Therapy,” NCT,Anti-Cancer Agents in Med. Chem., vol. 6. pp. 145-158 (2006).
Schnitmaker, J. J. et al., “Photodynamic Therapy: a Promising New Modality for the Treatment of Cancer,”Photochem. Photobiol. B: Biol., vol. 34, pp. 3-12 (1996).
Sibrian-Vazquez, M. et al., “Enhanced Cellular Uptake with a Cobaltacarborane-Porphyrin-HIV-1 Tat 48-60 Conjugate,”Bioconjugate Chem., vol. 17, pp. 928-934 (2006).
Vicente, M.. et al., “First Structural Characterization of a Covalent Bonded Porphyrin-Carborane System,”Chemical Communications, pp. 483-484 (2001).
Vicente, M., “Porphyrin-based sensitizers in the detection and treatment of cancer: recent progress,” Curr. Med. Chem., vol. 1, pp. 175-194 (2001).
Vicente, M.. et al., “Singlet Oxygen Generation and Dark Toxicity of anido- and acloso-Carboranylporphyrin,”Proceedings of SPIE, The International Society for Optical Engineering, vol. 5315, pp. 33-40 (2004).
Vicente, M. et al., “Syntheses and preliminary biological studies of fourmeso-tetra[(nido-carboranylmethyl)phenyl]porphyrins,” Bioorganic & Medicinal Chem., vol. 10, pp. 481-492 (2002).
Vicente, M. et al., “Syntheses of carbon-carbon linked carboranylated porphyrins for boron neutron capture therapy of cancer,”Tetr. Lett., vol. 41, pp. 7623-7627 (2000).
Vicente M. et al., “Syntheses of Phosphonate- and Amine-substituted Carboranylporphyrins for Boron Neutron Capture Therapy of Tumors,”Proceedings for the 12th International Symposium on Neutron Capture Therapy for Cancer, pp. 231-233 (2006).
Vicente, M. et al., “Synthesis, Dark Toxicity and Induction of in vitro DNA Photodamage by a Tetra(4-nido-carboranylphenyl)porphyrin,”Journal of Photochemistry and Photobiology B: Biology, vol. 68, pp. 123-132 (2002).
Vicente, M. et al., “Syntheses, Toxicity and Biodistribution of two 5,15-Di[3,5-(nido-carboranylmethyl)phenyl]porphyrin in EMT-6 Tumor Bearing Mice,”Bioorganic and Medicinal Chemistry, vol. 11, pp. 3101-3108 (20

Affiliated with

Also associated with

Rating

Boron-containing porphyrin compounds and their uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Boron-containing porphyrin compounds and their uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Boron-containing porphyrin compounds and their uses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4304614