Boron-containing lipiodol for boron neutron capture therapy of h

Details Boron-containing lipiodol for boron neutron capture therapy of h Boron-containing lipiodol for boron neutron capture therapy of h

1997-12-29

2000-09-12

Elliott, George C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

424 111, 424 121, 424450, 564 8, A61K 5112, A61K 9127, C07F 502

Patent

active

061178527

ABSTRACT:
The present invention discloses a boron-containing pharmaceutical composition useful in boron neutron capture therapy of hepatoma, which includes lipiodol, stibmicron boron powder, lecithin and unsaturated fatty acid. The lipiodol has a property of a high retention in hepatoma, the lecithin has a boron carrying capacity, and the unsaturated fatty acid has a function of rendering lecithin soluble in lipiodol.

REFERENCES:
patent: 4578391 (1986-03-01), Kawata
patent: 5648532 (1997-07-01), Hawthorne et al.
(2) Hawthorne et al. Preparation of Tumor-Specific Boron Compounds. 1. In Vitro Studies Using Boron-labeled antibodies and Elemental Boron as Neutron Targets. Journal of Medicinal Chemistry vol. 15, No. 5, pp. 449-452, May 1972.
F. I. Chou et al., Lipiodol Uptake and Retention by Human Hepatoma Cells, Nucl. Med. Biol., pp. 379-386, 1995.
F. I. Chou et al., Encapsulation of boron in lipiodol for boron neutron cpature therapy of hepatoma, Advances in Neutron Capture Therapy vol. II, Chemistry and Biology, Elsevier Science, 1997.
Chou et al, "Lipiodol Uptake and Retention by Human Hepatoma Cell", Nucl.Med.Biol. 22(3):379-386, 1995.

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