Boron compounds/complexes to control hair growth, and methods of

Details Boron compounds/complexes to control hair growth, and methods of Boron compounds/complexes to control hair growth, and methods of

1998-05-14

1999-11-16

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 64, A61K 3170

Patent

active

059858427

ABSTRACT:
Hair growth is affected by topical application of a boron containing compounds/complexes in which a central tetrahedral boron atom is covalently bound to four ligands. At least one of the ligands preferably includes an oxygen, nitrogen, carbon, or sulfur atom, and preferably all four ligands include at least one such atom. Preferred ligands are saccharides and amino acids, including fructose, sorbitol, mannitol, xylitol, sorbose, serine and threonine. Especially preferred ligands have a conformation with at least two hydroxyl groups, or one hydroxyl group and one amino group in a 1,2- and a 1,3- position relative to each other, providing a high association constant in the range of about 3,000 and about 20,000. The compounds/complexes are preferably provided in formulations which provide good transdermal delivery, including appropriate solvent systems, microemulsions, liposomes.

REFERENCES:
Waldon, D. Ew. J. Clin. Chem. Clin. Biochem 31(1) 41-5 1993.

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