Boron compounds and complexes as skin-rejuvenating agents

Details Boron compounds and complexes as skin-rejuvenating agents Boron compounds and complexes as skin-rejuvenating agents

1998-11-16

2000-06-27

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424401, 424657, 514 23, 514844, 514881, 514937, A61K 9127, A61K 700, A61K 9107

Patent

active

060804254

ABSTRACT:
Boron compounds/complexes, other than boric acid and boric acid salts, are utilized for rejuvenating of skin. The compounds/complexes have a central tetrahedral boron atom covalently bound to four ligands, which may be either identical or different from each other. Preferred ligands include an oxygen, nitrogen, carbon or sulfur atom, and more preferred ligands are saccharides or amino acids that form stable five- or six-membered rings with the boron atom. Especially preferred compounds have a dissociation constant of at least 3,000, and include a saccharide. Especially preferred complexes include a sodium, potassium, magnesium or calcium cation. The compounds/complexes are useful in rejuvenating skin, including decreasing skin wrinkles, improving skin thickness, increasing skin hydration, softness and elasticity, improving the skin color, and decreasing the number and size of age spots. The compounds/complexes are preferably provided in a suitable solvent system, a microemuslion or macroemulsion form, or a suitable liposome, and may be applied in any suitable form, including creams, bath salts, cosmetics, and shampoos.

REFERENCES:
patent: 5628990 (1997-05-01), Murphy

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