Boron analogs of amino acid/peptide protease inhibitors

Details Boron analogs of amino acid/peptide protease inhibitors Boron analogs of amino acid/peptide protease inhibitors

1988-05-27

1990-10-16

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

548110, 549213, 560 29, 564 8, C07K 508

Patent

active

049636553

ABSTRACT:
A method of inhibiting protease activity, growth, and colony formation in mammalian tumor cells by boronic acid analogs of amino acids, dipeptides and tripeptides. A method of coupling a boronic acid analog of an amino acid to other N-protected amino acids or N-protected dipeptides and compositions formed from the coupled products.

REFERENCES:
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 4537773 (1985-08-01), Shenvi
B. Goz et al., Biochem. Pharmacol., 35, 3587 (1986).
D. H. Kinder et al., J. Med. Chem., 28, 1917 (1985).

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