Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-05-31
1998-12-29
Feisee, Lila
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4242041, 4351723, C07H 2104, C12N 1531
Patent
active
058544178
ABSTRACT:
Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV Infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.
REFERENCES:
Koprowski, H., Detection of Serum Antibodies to Borna Disease Virus in Patients with Psychiatric Disorders, Science, vol. 228, pp. 755-756, (1985).
Haas, et al., Purification and Properties of an Intranuclear Virus-specific Antigen from Tissue Infected with Borna Disease Virus, The Journal of General Virology, (1986), 67, pp. 235-241.
Schadler, et al., Isolation and Characterization of a 14500 Molecular Weight Protein from Brains and Tissue Cultures Persistently Infected with Borna Disease Virus, The Journal of General Virology, (1985), 66, pp. 2479-2484.
Young, et al., Genes for the major protein antigens of the leprosy parasite Mycobacterium leprae, Nature, vol. 316, Aug. 1, 1985, pp. 450-452.
Lipkin et al Proc Natl Acad Sci USA vol. 87:4184-4188 1990.
Helfman et al Methods in Enzymology vol. 152:451-457 1987.
Young et al Proc Natl Acad Sci USA vol. 80:1194-1198 1983.
Clements Janice
Narayan Opendra
Richt Juergen
Vandewoude Susan
Feisee Lila
Reeves Julie E.
The Johns Hopkins University
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