Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1998-12-29
2000-05-09
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 71, 530350, 530826, 935 2, 935 3, 935 6, 935 12, 935 76, 935 77, C12Q 170
Patent
active
060602368
ABSTRACT:
Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.
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Schadler et al., "Isolation and Characterization of a 14500 Molecular Weight Protein from Brains and Tissue Cultures Persistently Infected with Borna Disease Virus," The Journal of General Virology, (1985), 66, pp. 2479-2484.
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Lipkin et al., "Isolation and characterization of Borna disease agent cDNA clones", Proc. Natl. Acad. Sci. USA, vol. 87, pp. 4184-4188, Jun. 1990.
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Clements Janice E.
Narayan Opendra
Richt Juergen A.
Vandewoude Susan
Stucker Jeffrey
The Johns Hopkins University School of Medicine
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