Borna disease viral sequences, diagnostics and therapeutics for

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4242041, 435 5, 435975, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530350, 5303879, 5303883, 5303894, A61K 3912, C07K 700, C07K 1408, C07K 1610, C12Q 170

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active

060775106

ABSTRACT:
The present invention presents: genomic nucleotide sequence of Borna disease virus, nucleotide and amino acid sequences of Borna disease virus proteins, recombinant viral proteins, vectors and cells containing the sequences or encoding the proteins, ligand binding to these proteins such as antibodies, and the diagnostic and therapeutic uses of the foregoing.

REFERENCES:
patent: 4676980 (1987-06-01), Segal et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5219740 (1993-06-01), Miller et al.
patent: 5256553 (1993-10-01), Overell
Barik, S., et al., "Nucleotide Sequence Analysis of the L Gene of Vescular Stomatitis Virus (New Jersey Serotype): Identification of Conserved Domains in L Proteins of Nonsegmented Negative-Strand RNA Viruses", Virology, 175:332 (1990).
Battegay, M., et al., "Impairment and Delay of Neutralizing Antiviral Antibody Responses by Virus-Specific Cytotoxic T Cells", J. Immunol., 151:5408 (1993).
Bause-Niedrig, I. M., et al., "Borna disease virus-specific antigens. II. The Soluble antigen is a protein complex", Vet. Immunol. Immunopathol., 31:361 (1992).
Bode, L., et al., "Borna Disease Virus-specific Antibodies in Patients with HIV Infection and with Mental Disorders", Lancet ii:689 (1988).
Briese, T., et al., "Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells", Proc. Natl. Acad. Sci., USA, 89:11486 (1992).
Briese, T., et al., "Genomic organization of Borna disease virus", Proc. Natl. Acad. Sci. USA, 91:4362 (1994).
Briese, T., et al., "Enzyme-Linked Immunosorbent Assay for Detecting Antibodies to Borna Disease Virus-Specific Proteins", J. Clin. Microbiol., 33:348 (1995).
Carbone, K. M., et al., "Borna Disease Virus Replicates in Astrocytes, Schwann Cells and Ependymal Cells in Persistently Infected Rats: Location of Viral Genomic and Messenger RNAs by In Situ Hybridization", J. Neuropathol. Exp. Neurol., 50:205 (1991).
Carbone, K. M., et al., "Characterization of a Glial Cell Line Persistently Infected with Borna Disease Virus (BDV): Influence of Neurotrophic Factors on BDV Protein and RNA Expression", J. Virol., 67:1453 (1993).
Cubitt, B., et al., "Sequence and Genome Organization of Borna Disease Virus", J. Virol., 68:1382 (1994).
de la Torre, J. C., "Molecular Biology of Borna Disease Virus: Prototype of a New Group of Animal Viruses", J. Virol. 68:7669 (1994).
de la Torre, J. C., et al., "Molecular Characterization of the Borna Disease Agent", Virology 179:853 (1990).
Dietzschold, B., et al., "Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system", Proc. Natl. Acad. Sci. USA, 89:7252 (1992).
Dimmock, N. J., "Neutralization of Animal Viruses", A. Capron, et al. (ed.), "Current Topics in Microbiology and Immunology", Springer-Verlag, Berlin (1993).
Fujinami, R. S., et al., "Survival of Athymic (nu
u Mice after Theiler's Murine Encephalomyelitis Virus Infection by Passive Administration of Neutralizing Monoclonal Antibody", J. Virol., 63:2081 (1989).
Haas, B., et al., "Purification and Properties of an Intranuclear Virus-specific Antigen from Tissue Infected with Borna Disease Virus", J. Gen. Virol., 67:235 (1986).
Hatalski, C. G., et al., "Neutralizing Antibodies in Borna Disease Virus-Infected Rats", J. Virol., 69:741 (1995).
Herzog, S., et al., "Effect of Borna Disease Virus Infection on Athymic Rats", J. Gen. Virol., 66:503 (1985).
Hirano, N., et al., "Persistent, Tolerant or Subacute Infection in Borna Disease Virus-infected Rats", J. Gen. Virol., 64:1521 (1983).
Keene, J. D., et al., "Terminal Sequences of Vesicular Stomatitis Virus RNA Are Both Complementary and Conserved", J. Virol. 32:167 (1979).
Kliche, S., et al., "Characterization of a Borna Disease Virus Glycoprotein, gp18", J. Virol., 68:6918 (1994).
Kozak, M., "An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs", Nucleic Acids Res., 15:8125 (1987).
Lipkin, W. I., et al., "Isolation and characterization of Borna disease agent cDNA clones", Proc. Natl. Acad. Sci USA, 87:4184 (1990).
Lipkin, W. I., et al., "Borna disease virus: molecular analysis of a neurotropic infections agent", Microbial Pathogenesis, 13:167 (1992).
Ludwig, H., et al., "The Cerebrospinal Fluid of Rabbits Infected with Borna Disease Virus", Arch. Virol., 55:209 (1977).
Ludwig, H., et al., "Demonstration of Specific Antibodies in the Central Nervous System of Horses Naturally Infected with Borna Disease Virus", Med. Microbiol. Immunol., 163:215 (1977).
Ludwig, H., et al., "Borna Disease: A Persistent Virus Infection of the Central Nervous System", Prog. Med. Virol., 35:107 (1988).
Mandl, C. W., et al., "Sequencing the Termini of Capped Viral RNA by 5'-3' Ligation and PCR", BioTechniques, 10:484 (1991).
Maniatis, et al., Molecular Cloning--A Laboratory Manual, Cold Spring Harbor (1984).
McClure, M. A., et al., "Sequence Similarity between Borna Disease Virus p40 and a Duplicated Domain within the Paramyxovirus and Rhabdovirus Polymerase Proteins", J. Virol., 66:6572 (1992).
Narayan, O., et al., "Pathogenesis of Borna Disease in Rats: Immune-Mediated Viral Ophthalmoencephalopathy Causing Blindness and Behavioral Abnormalities", J. Inf. Dis., 148:305 (1983).
Narayan, O., et al., "Behavorial Disease in Rats Caused by Immunopathological Responses to Persistent Borna Virus in the Brain", Science, 220:1401 (1983).
Pauli, G., et al., "Focus-Immunoassay for Borna Disease Virus-Specific Antigens", Zbl. Vet. Med. [B], 31:552 (1984).
Poch, O., et al., "Identification of four conserved motifs among the RNA-dependent polymerase encoding elements", EMBO J., 8:3867 (1989).
Pringle, C. R., et al., "The order Mononegavirales", Arch. Virol., 117:137 (1991).
Pyper, J. M., et al., "Genomic Organization of the Structural Proteins of Borna Disease Virus Revealed by a cDNA Clone Encoding the 38-kDa Protein", Virology, 195:229 (1993).
Richt, J. A., et al., "Analysis of Borna disease virus-specific RNAs in infected cells and tissues", J. Gen. Virol., 72:2251 (1991).
Richt, J. A., et al., "Infection with Borna Disease Virus: Molecular and Immunobiological Characterization of the Agent", Clin. Infections Diseases, 14:1240 (1992).
Rott, R., et al., "Detection of Serum Antibodies to Borna Disease Virus in Patients with Psychiatric Disorders", Science, 228:755 (1985).
Rubin, S. A., et al., "Borna Disease Virus in Mice: Host-Specific Differences in Disease Expression", J. Virol., 67:548 (1993).
Schadler, R., et al., "Isolation and Characterization of a 14500 Molecular Weight Protein from Brains and Tissue Cultures Persistently Infected with Borna Disease Virus", J. Gen. Virol., 66:2479 (1985).
Schneeman, A., et al., "Identification of Signal Sequences That Control Transcription of Borna Disease Virus, a Nonsegmented, Negative-Strand RNA Virus", J. Virol., 68:6514 (1994).
Schneider, P. A., et al., "Sequence Conservation in Field and Experimental Isolates of Borna Disease Virus", J. Virol., 68:63 (1994).
Schneider, P.A., et al., "RNA Splicing in Borna Disease Virus, a Nonsegmented, Negative-Strandad RNA Virus", J. Virol., 68:5007 (1994).
Schnell, M. J., "Infectious rabies viruses from cloned cDNA", EMBO J., 13(18):4195 (1994).
Sprankel, H., et al., "Behavior Alterations in Tree Shrews (Tupaia glis, Diard 1820) Induced by Borna Disease Virus", Med. Microbiol. Immunol., 165:1 (1978).
Stitz, L., et al., "Borna Disease In Rhesus Monkeys as a Model for Uveo-Cerebral Symptoms", J. Med. Virol., 6:333 (1980).
Stitz, L., et al., "Preventive Effects of Early Anti-CD4 or Anti-CD8 Treatment on Borna Disease in Rats", J. Virol., 66:3316 (1992).
Thibault, K. J., M. S. thesis, "Identification and Preliminary Characterization of cDNAs Encoding Borna Disease Virus p24 and p40", University of California, Irvine (1992) Title Page and Table of Contents and Figures.
Thiedemann, N., et al., "Antigenic relationship and further characterization of two major Borna disease virus-specific proteins", J. Gen. Virol., 73:1

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