Bordetella pertussis variants

Details Bordetella pertussis variants Bordetella pertussis variants

1991-10-11

1993-06-29

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 530350, 435 701, 435 711, 435 712, 435243, 435244, 435822, 4352521, A61K 3902, C12P 2104

Patent

active

052232557

ABSTRACT:
A Bordetella pertussis variant which produces a pertussis toxin mutant protein partially devoid of subunits. When the variants of the present invention are cultured, a pertussis toxin mutant protein partially devoid of subunits, particularly at least subunit S1, can be harvested from the culture. The thus-obtained pertussis toxin mutant protein partially devoid of subunits can be applied to the preparation of a pertussis vaccine by a conventional method.

REFERENCES:
patent: 4687738 (1987-08-01), Ginnaga et al.
Marchitto et al, Infection and Immunity, vol. 55, No. 5, pp. 1309-1313, May 1987.
Perera et al, Journal of General Microbiology, vol. 133, pp. 2427-2435, 1987.
Patent Abstracts of Japan, vol. 8, No. 67 (C-216)[1504], Mar. 29, 1984; and JP-A-58 222 032 (Teijin K.K.) Dec. 23, 1983.
A. C. Wardlaw and R. Parton, Pharmac. Ther. vol. 19, 1-53, 1983.
Y. Sato, M. Kimura and H. Fukumi, The Lancet, Jan. 21, 122-126, 1984.
C. Locht and J. M. Keith, Science, vol. 232, 1258-1264, 1986.

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