Borderline active dosage forms of beta blockers

Details Borderline active dosage forms of beta blockers Borderline active dosage forms of beta blockers

1994-10-13

1996-03-05

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424464, 514821, A61F 1300, A61K 920

Patent

active

054965608

ABSTRACT:
For short-term therapy of transient functional cardiovascular symptoms, borderline active dosage forms of beta blockers are used which produce in the body only the borderline active concentrations of active ingredient which produce no significant changes in the physiological values in the cardiovascular system under resting conditions for the respective specific beta blocker used and significantly reduce adrenergically induced transient stimulation effects. Oral, transdermal, or topical dosage forms are particularly advantageous. A differentiated therapy of functional symptoms which does not exist with the customary dosage forms of beta blockers designed for long-term therapies is possible. Both the quality of life and the risk-benefit ratio of the beta blockers are improved. The duration of the therapy also does not have to be extended beyond the symptomatically required scale since no rebound danger exists after withdrawal. As an additional and now indication, this also permits the short-term use for the primary therapy of sleep disturbances, within the framework of vegetative syndromes, in particular, within the framework of postmenopausal symptoms.

REFERENCES:
Facts and Comparisons, Sewester et al., J. B. Lippincott Co., Jan. 1993, p. 158r.
Facts and Comparisons, Kastrup et al., J. B. Lippincott Co., Apr. 1985, pp. 158H-159.

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