Boosting of immunogenic conjugate vaccinations by unconjugated b

Details Boosting of immunogenic conjugate vaccinations by unconjugated b Boosting of immunogenic conjugate vaccinations by unconjugated b

1985-05-08

1988-08-09

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, H61K 3902, H61K 39095

Patent

active

047627131

ABSTRACT:
This invention relates to immunogenic conjugates of capsular polymers or polymer fragments from bacterial pathogens and bacterial toxins, toxoids or subunits. The invention also relates to methods for the preparation of the conjugates and a vaccine containing the conjugates which elicits effective levels of anti-capsular polymer antibodies in human infants. Also disclosed are methods for inducing active immunization against systemic infection in human infants caused by bacterial pathogens, by administering an effective amount of the above-described conjugate, followed by the capsular polymer fragments alone.

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