Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone
Patent
1997-10-01
2000-10-24
Willse, David H.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Bone
623 11, 427 227, A61F 228
Patent
active
061360295
ABSTRACT:
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume and having open interconnecting interstices extending throughout said volume and opening through said surface. The article comprises a continuous strong framework structure having interstices which interconnect throughout the bulk volume and a second continuous material occupying at least a portion of the same bulk volume as the framework structure. The second material comprises an osteoinductive and/or osteoconductive composition. This composition may be present in one of several forms. One of these is as a coating on the surface of the framework structure. A second form is in the form of a composite, intimately mixed with the framework material within the framework struts. The third form is as a porous mass within the interstices of the framework structure, having pores which are interconnecting with themselves, and with the interstices of the framework structure. Desirably, the porous osteoinductive or osteoconductive composition extends throughout said bulk volume. In a preferred embodiment, the framework structure is formed of a ceramic material. In a further embodiment, the framework structure may be further structurally reinforced with a dense material component integrally affixed thereto.
REFERENCES:
patent: 4000525 (1977-01-01), Klawitter et al.
patent: 4237559 (1980-12-01), Borom
patent: 4343704 (1982-08-01), Brockmeyer
patent: 4599085 (1986-07-01), Riess et al.
patent: 4626392 (1986-12-01), Kondo et al.
patent: 4722870 (1988-02-01), White
patent: 4957509 (1990-09-01), Tamari et al.
patent: 4976736 (1990-12-01), White et al.
patent: 4983182 (1991-01-01), Kijima et al.
patent: 5001169 (1991-03-01), Nathan et al.
patent: 5007930 (1991-04-01), Dorman et al.
patent: 5037438 (1991-08-01), Davidson
patent: 5084051 (1992-01-01), Tormala et al.
patent: 5152791 (1992-10-01), Hakamatsuka et al.
patent: 5185177 (1993-02-01), Kijima et al.
patent: 5192325 (1993-03-01), Kijima et al.
patent: 5205921 (1993-04-01), Shirkanzadeh
patent: 5231169 (1993-07-01), Constantz et al.
patent: 5282861 (1994-02-01), Kaplan
patent: 5356436 (1994-10-01), Nonami et al.
patent: 5366508 (1994-11-01), Brekke
patent: 5458643 (1995-10-01), Oka et al.
patent: 5464440 (1995-11-01), Johansson
patent: 5522894 (1996-06-01), Klaus
patent: 5549123 (1996-08-01), Okayama et al.
patent: 5549685 (1996-08-01), Hayes
patent: 5626861 (1997-05-01), Laurencin et al.
patent: 5716414 (1998-02-01), Caldarise
patent: 5725813 (1998-03-01), Nies
patent: 5783248 (1998-07-01), Ruey et al.
Aksaci, D., et al., "Porous Fluorapatite/Spinel Osteoceramic For Bone Bridges", Phosphorus: Studies in Inorganic Chemistry, vol. 6, 1985, pp. 283-301.
McGee, Thomas D., et al., "General Requirements for a Successful Orthopedic Implant", pp. 69-82.
Ito, Kuniomi, et al., "Osteogenic Activity of Synthetic Hydroxylapatite With Controlled Texture-on the Relationship of Osteogenic Quantity . . . ", CRC Handbook of Bioactive Ceramics, vol. II, pp. 39-44.
Johnson, Kenneth D., et al., "Porous Ceramics as Bone Graft Substitutes in Long Bone Defects . . . ", J. Orthop. Rev., vol. 14, No. 3, 1996, pp. 351-369.
"Bone Grafts and Bone Substitutes", Orthopedic Network News, vol. 6, No. 4, Oct. 1995, pp. 7-9.
Constantz, Brent R., et al., "Skeletal Repair by in Situ Formation of the Mineral Phase of Bone", Science, vol. 267, Mar. 24, 1995, pp. 1796-1799.
Chaki, T.K., et al, "Strengthening Behavior of Hydroxyapatite-Silver Composite", Bioceramics: Materials and Applications, pp. 235-244.
Damien, C., et al., "Bone Graft and Bone Graft Substitutes: A Review of Current Technology and Applications", J. App. Biomat., vol. 2, 1991, pp. 187-208.
Ioku, Koji, et al., "Dense/porous Layered Apatite Ceramics Prepared by HIP Post-sintering", J. Mat. Science, 1989, pp. 1203-1204.
Wu, Jenn-Ming, et al., "Sintering of Hydroxylapatite-zirconia Composite Materials", J. Mat. Science, 1988, pp. 3771-3777.
Li, J., et al., "High-strength biofunctional zirconia: mechanical properties and static fatigue behavior of zirconia-apatite composites", J. Bio. Sci. Mat., 1993, pp. 50-54.
Suda, Akio, et al., "Biocompatibility of Zirconia Dispersed Hydroxyaptite Ceramics", J. Jap. Orthop. Assoc., vol. 64, pp. 249-258.
Takaoka, Kunio, et al., "Ectopic Bone Induction on and in Porous Hydroxyapatite Combined with Collagen and Bone Morphogenetic Protein", Clinical Orthopedics, No. 234, Sep. 1988, pp. 250-254.
Mattioli-Belmonte, et al., "Osteoinduction in the Presence of Chitosan-Coated Porous Hydroxyapatite", J. Bio. Comp. Poly., vol. 10, Jul. 1995, pp. 249-257.
Wan, Andrew, et al., "Hydroxyapatite Modified Chitin as Potential Hard Tissue Substitute Material", J. Bio. Mat. Res. [38] 3 (1997), pp. 235-241.
Zhang, Qi-Qing, "Porous Hydroxyapatite Reinforced with Collagen Protein", Marcel Dekker, Inc., 1996, pp. 693-702.
Gao, T., et al., "Enhanced healing of segmental tibial defects in sheep by a composite bone substitute composed of tricalcium phosphate cylinder, bone . . . ", J. Bio. Mat. Res., vol. 32, (1996) pp. 505-512.
Verheyen, et al., "Hydroxylapatite/poly (L-lactide) composites: An animal study on push-out strengths and interface histology", J. Bio. Mat. Res., vol. 27, (1993), pp. 433-444.
TenHuisen, K., et al., "Formation and properties of a synthetic bone composite: Hydroxyapatite-collagen", J. Bio. Mat. Res., vol. 29, (1995), pp. 803-810.
Muller-Mai, C., et al., "Nanoapatite and organoapatite implants in bone: Histology and ultrastructure of the interface", J. Bio. Mat. Res., vol. 29, (1995) pp. 9-18.
Tian, Y., "A Novel Chondrocyte-Seeded Hydroxyapatite-Collagen Scaffold for Cartilage Repair", Fifth World Biomaterials Congress, May 29-Jun. 2, 1996.
Johnson James R.
Johnson Wesley D.
Marx Jeffrey G.
Nguyen Dinh X.
Phillips-Origen Ceramic Technology, LLC
Willse David H.
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