Bone-stimulating, non-vasoactive parathyroid hormone variants

Details Bone-stimulating, non-vasoactive parathyroid hormone variants Bone-stimulating, non-vasoactive parathyroid hormone variants

1994-10-31

1997-02-04

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3829, C07K 14635

Patent

active

055997929

ABSTRACT:
Described herein are Met.sup.8 -substituted variants of parathyroid hormone that retain bone stimulating activity yet, unlike their native counterparts, have substantially no vasoactivity. Their production using recombinant DNA-based techniques is also described, as is their therapeutic use, e.g. in the treatment of osteoporosis.

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