Bone seeking Tc-99m complexes of phosphonate derivatives of poly

Details Bone seeking Tc-99m complexes of phosphonate derivatives of poly Bone seeking Tc-99m complexes of phosphonate derivatives of poly

1984-07-02

1986-08-19

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

2605025R, 2605024P, 424 9, 534 14, 564 12, A61K 4300, A61K 4900, A61K 4902

Patent

active

046069070

ABSTRACT:
New stable complexing agents for radionuclides which are phosphonate derivatives of certain polyamidoamines have been found which are useful in imaging the skeletal system in animals. Even though the complexing agents have high molecular weights the complexes clear rapidly and very efficiently through the kidneys, with large amounts being taken up in the bone. The ratio of uptake in bone to that in surrounding soft tissue is high even at relatively short times after injection.

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