Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-07-12
1996-07-23
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 793, 435 794, 435971, 435975, 436536, 436538, 436540, 436808, 530323, 5303881, 5303891, 5303911, 5303913, G01N 3353, G01N 33535
Patent
active
055388531
ABSTRACT:
An antibody raised to type I collagen carboxyterminal cross-linked telopeptide isolated from decalcified human or animal bone, may be used in an assay to determine the concentration of liberated carboxyterminal telopeptide region of the type I collagen molecule in a sample. When the sample is a body fluid such as serum or urine the degradation product measured is resistant to further degradation, since it contains a multivalent intermolecular cross-link, and can thus be found in the body fluid. The assay may be used to assess the degradation of type I collagen, the major organic constituent of bone matrix.
REFERENCES:
patent: 4973666 (1990-11-01), Eyre
Kuhn, "Chemical Properties of Collagen", in Immunochemistry of the Extracellular Matrix, H. Furthmayr, Ed., CRC Press, Inc., Boca Raton, Fla. (1982), pp. 1-29.
Hartmann et al., "Radioimmunoassay of Type I Collagen that Mainly Detects Degradation Products in Serum: Application to Patients with Liver Disease", Clin. Chem. vol. 36, No. 3, pp. 421-426 (1990).
Wu et al., "Fine Powdering Exposes the Mineral-Protected Collagen of Bone to Protease Digestion", Calcif. Tissue Int., vol. 42, pp. 243-247, (1988).
Risteli et al., "Bone Resorption Assay Based on a Peptide Liberated During Type I Collagen Degradation", J. Bone Min. Res., 6 (Supp.1), SZ51(Abstract 670), 1991.
Ericksen et al., "Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Serum (S-ICTP): A New Bone Resorption Marker", J. Bone Min Res., 6(Suppl), 5243 (Abstract 637), 1991.
Risteli Juha P.
Risteli Leila T.
Orion Corporation, Orion Diagnostica
Scheiner Toni R.
Wolski Susan C.
LandOfFree
Bone resorption assay based on a peptide liberated during collag does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bone resorption assay based on a peptide liberated during collag, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bone resorption assay based on a peptide liberated during collag will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-712145