Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-08-26
1995-10-24
Martinell, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 435212, 536 232, C12P 2100, C12P 2102, C12N 1512
Patent
active
054609518
ABSTRACT:
A bone-related carboxypeptidase-like protein named OSF-5 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein which belongs to a group of carboxypeptidase molecules.
OSF-5 acts as an adhesion molecule or a growth factor which takes part in the process of osteogenesis at the site of bone induction. OSF-5 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.
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"Inhibition of Bone Resorption In Vitro by Human Enkephalinase (EC 3.424.11), a Neutral Metalloendopeptidase", Ibbotson et al., Journal of Bone and Mineral Research, 7(3):273-279 (1992).
S. Howell, et al., Membrane Peptidases on Human Osteoblast-Like Cells in Culture: Hydrolysis of Calcitonin and Hormonal Regulation of Endopeptidase-24 .11; Biochemical Journal, vol. 290, part 1: 159-164 (Feb. 15, 1993).
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Amann Egon
Kawai Shinji
Okazaki Makoto
Takeshita Sunao
Hoechst Japan Limited
Martinell James
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