Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone
Patent
1996-10-18
1997-12-30
Prebilic, Paul B.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Bone
623 22, 623 23, 433226, A61F 228
Patent
active
057024464
ABSTRACT:
A bone prosthesis having a porous or mesh type mating surface for attachment to bone and at least one continuous hollow internal chamber is disclosed. The prosthesis also includes at least one portal and at least one channel extending from each hollow chamber that allows communication between the chamber of the prosthesis and the mating surface of the device. Biomaterial for enhancing bone growth is injected in fluid form through a portal of the device into a hollow chamber, simultaneous with or after press fitting the prosthesis into the bone. Biomaterial thereby reaches bone mating surfaces through one or more channels. Bony growth at a mating surface of the prosthesis is enhanced, and union of the prosthesis with bone is thereby promoted.
REFERENCES:
patent: 4012796 (1977-03-01), Weisman et al.
patent: 4120730 (1978-10-01), Trojer et al.
patent: 4274163 (1981-06-01), Malcom et al.
patent: 4279249 (1981-07-01), Vert et al.
patent: 4355426 (1982-10-01), MacGregor
patent: 4546500 (1985-10-01), Bell
patent: 4563489 (1986-01-01), Urist
patent: 4698063 (1987-10-01), Link et al.
patent: 4750905 (1988-06-01), Koeneman et al.
patent: 4795467 (1989-01-01), Piez et al.
patent: 4795475 (1989-01-01), Walker
patent: 4804382 (1989-02-01), Turina et al.
patent: 4920203 (1990-04-01), Tang et al.
patent: 4938772 (1990-07-01), Frey et al.
patent: 4978358 (1990-12-01), Bobyn
patent: 5098779 (1992-03-01), Kronzler et al.
patent: 5116377 (1992-05-01), Skripitz et al.
patent: 5250584 (1993-10-01), Ikada et al.
patent: 5250585 (1993-10-01), Guggenberger et al.
patent: 5258029 (1993-11-01), Chu et al.
patent: 5263986 (1993-11-01), Noiles et al.
patent: 5281419 (1994-01-01), Tuan et al.
patent: 5376123 (1994-12-01), Klaue et al.
patent: 5522895 (1996-06-01), Mikos
Albrektsson and Hansson, "An Ultrastructural Characterization of the Interface Between Bone and Sputtered Titanium or Stainless Steel Surfaces," Biomaterials, 7:201-205, May 1986.
Aldinger et al., "Bone Morphogenetic Protein: A Review," International Orthop. (SICOT), 15:169-177, 1991.
Athanasiou et al., "Biodegradable Carriers of GF-.beta. in Rabbit Osteochondral Defects," 39th Annual Meeting, Orthopaedic Research Society, San Francisco, CA, Feb. 15-18, 1993.
Bobyn et al., "The Optimum Pore size for the Fixation of Porous-Surfaced Metal Implants by the Ingrowth of Bone," Clinical Orthopaedics and Related Research, 150:263-270, Jul./Aug. 1980.
Buser et al., "Influence of Surface characteristics on Bone Integration of Titanium Implants. A Histomorphometric Study in Miniature Pigs," Journal of Biomedical Materials Research, 25:889-902, 1991.
Cameron et al., "The Rate of Bone Ingrowth into Porous Meal," J. Biomed. Mater. Res., 10:295-302, 1976.
Collier et al., "Bone Ingrowth into Dynamically Loaded Porous-Coated Intramedulllary Nails," J. Biomed. Mater. Res. Symposium, 10(7):485-492, 1976.
Collier et al., "Macroscopic and Microscopic Evidence of Prosthetic Fixation with Porous-Coated Materials," Clinical Orthopaedics and Related Research, 235:173-180, Oct. 1988.
Cook et al., "Interface Mechanics and Bone Growth into Porous Co-Cr-Mo Alloy Implants," Clinical Orthopaedics and Related Research, 193:271-280, Mar. 1985.
D'Alessandro et al., "Purification, Characterization, and Activity of Recombinant Human BMP-5," Journal of Cellular Biochemistry, Supplement 15;166, 1991.
Ferguson et al., "Bovine Bone Morphogenetic Protein (bBMP) Fraction-Induced Repair of Craniotomy Defects in the Rhesus Monkey (Macaca speciosa)," Clinical Orthopaedics and Related Research, 219:251-258, Jun. 1987.
Geesink et al., "Chemical Implant Fixation Using Hydroxyl-Apatite Coatings: The Development of a Human Total Hip Prosthesis for Chemical Fixation to Bone Using Hydroxyl-Apatite coatings on Titanium Substrates," Clinical Orthopaedics and Related Research, 225:147-170, 1987.
Geesink, "Hydroxyapatite-Coated Total Hip Prostheses", Clinical Orthopaedics and Related Research, 261:39-58, 1990.
Hulbert et al., "Attachment of Prostheses to the Musculoskeletal System by Tissue Ingrowth and Mechanical Interlocking," J. Biomed. Mater. Res., 4:1-23, 1973.
Jansen et al., "Histologic Evaluation of the Osseous Adaptation to Titanium and Hydroxyapatit-Coated Titanium Implants," Journal of Biomedical Materials Research, 25:973-989, 1991.
Kellmann et al., "Analysis of the Diurnal Expression Patterns of the Tomato Chlorophyll a/b Binding Protein Genes. Influence of Light and Characterization of the Gene Family," Photochemistry and Photobiology, 52(1):pp. 35-41, 1990.
Lee et al., "Healing of Large Segmental Defects in Rat Femurs is Aided by RhBMP-2 Matrix," J. Biomedical Materials Research, 28:1149-1156, 1994.
Lind et al., "Transforming Growth Factor-.beta. enhances Fracture Healing in Rabbit Tibiae," 39th Annual Meeting, Orthopaedic Research Society, San Francisco, CA, Feb. 15-18, 1993.
Lindholm et al., "Bovine Bone Morphogenetic Protein (bBMP) Induced Repair of Skull Trephine Defects in sheep," Clinical Orthopaedics and Related Research, 227:265-268, 1988.
Miller et al., "The Induction of Bone by an Osteogenic Protein and the Conduction of Bone by Porous Hydroxyapatite: A Laboratory Study in the Rabbit," Plastic and Reconstructive Surgery, 87(1):87-95 , Jan. 1991.
Mizutani and Urist, "The Nature of Bone Morphogenetic Protein (BMP) Fractions Derived from Bovine Bone Matrix Gelatin," Clinical Orthopaedics and Related Research, 171:213-223, Nov./Dec. 1982.
Ohgushi et al., "Bone Formation Process in Porous Calcium Carbonate and Hydroxyapatite," Journal of Biomedical Materials Research, 26:885-895, 1992.
Oonishi, "Orthopaedic Applications of Hydroxyapatite," Biomaterials, 12:171-178, Mar., 1991.
Pachance, "Collagen-Based Devices for Soft Tissue Repair," Journal of Biomedical Materials Research (Applied Biomaterials), 33:35-40, 1996.
Sato et al., "Induced Regeneration of Calvaria by Bone Morphogenetic Protein (BMP) in Dogs," Clinical Orthopaedics and Related Research, 197:301-311, Jul./Aug. 1985.
Syftestad and Urist, "Bone Aging," Clinical Orthopaedics and Related Research, 162:288-297, Jan./Feb. 1982.
Takagi and Urist, "The Reaction of the Dura to Bone Morphogenetic Protein (BMP) in Repair of Skull Defects," Ann Surg, 196(1):100-109, Jul. 1982.
Trope et al., "Fifth:fifty poly (DL glycolic acid-lactic acid) copolymer as a drug delivery system for 5-fluorouracil: a histopathological evaluation." Canadian Journal of Ophthalmology, 29(4):168-71, 1994 (Abstract).
Urist et al., "Osteogenetic Competence," Clinical Orthopaedics and Related Research, 64:194-220, May/Jun. 1969.
Wlodarski and Reddi, "Importance of Skeletal Muscle Environment for Ectopic Bone Induction in Mice," Folia Biol, 34(4):425-434, 1986.
Agrawal C. Mauli
Schenck Robert C.
Board of Regents , The University of Texas System
Prebilic Paul B.
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