Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1994-08-12
1999-10-26
Reeves, Julie
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435325, 435355, 435366, 435378, 530412, 530413, 5303882, 5303887, 5303896, 4241411, 4241391, 4241731, C12N 1585, A61K 3532
Patent
active
059727039
ABSTRACT:
Disclosed are methods, compositions and uses of bone precursor cells. Bone precursor cells are cells which are not hematopietic and which can differentiate into osteoblasts upon exposure to a bone growth factor and deposit calcium into the extracellular matrix. In addition, methods of differentiating bone precursor cells into osteoblasts are disclosed. Bone precursor cells are useful in the treatment of certain bone related disorders and diseases such as, promoting fracture repair.
REFERENCES:
patent: 4904259 (1990-02-01), Itay
patent: 5061620 (1991-10-01), Tsukamoto et al.
patent: 5108753 (1992-04-01), Kuberasampath et al.
patent: 5118667 (1992-06-01), Adams et al.
patent: 5197985 (1993-03-01), Caplan et al.
patent: 5226914 (1993-07-01), Caplan et al.
Roitt et al Immunology J Lippincott Company, Philadelphia, Figures 25.20, Feb. 1991.
Dorland's llustrated Medical Dictionary 27th Edition W. B. Saunders Co. pp. 256 and 983, 1988.
Bruder and Caplan, "First bone formation and the dissection of an osteogenic lineage in the embryonic chick tibia is revealed by monoclonal antibodies against osteoblasts," Bone, 10(5):359-75, 1989. Abstract only.
Chiba and Matsuyama, "Immunohistochemical localization of bone Gla protein and osteonectin in normal human bone and cartilage tissues, and in osteosarcomas and chondrosaracomas," Nippon Seikeigeka Gakkai Zasshi, 67(5):463-72, May, 1993, Medline abstract.
Choong et al., "Induction of osteoblast differentiation by ascorbic acid, retinoic acid, and calcitrol," Front. Osteosarcoma Res., pp. 331-334, 1993. Abstract only.
Harris et al., "Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts," J. Bone Miner. Res., 9(6):855-63, Jun., 1994. Abstract only.
Haynesworth et al., "Characterization of Cells with Osteogenic Potential from Human Marrow," Bone, 13:81-88, 1992.
Long et al., "Regulation of Human Bone Marrow-derived Osteoprogenitor Cells by Osteogenic Growth Factors," J. Clin. Invest., 95:881-887, Feb., 1995.
Malaval et al., "Cellular expression of bone-related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures," J. Cell Physiol., 158(3):555-72, Mar., 1994.
Mohan and Baylink, "Bone Growth Factors," Clin. Orthop., 263:30-48, 1991.
Shortman, "The Separation of Lymphoid Cells on the Basis of Physical Parameters: Separation of B- and T-Cell Subsets and Characterization of B-Cell Differentiation Stages," In: Methods of Cell Separation, vol. 1, Plenum Press, New York, pp. 229-249, 1977.
Turksen et al., "Isolation of monoclonal antibodies recognizing rat bone-associated molecules in vitro and in vivo," J. Histochem. Cytochem., 40(9):1339-52, Sep., 1992.
Yamaguchi et al., "Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro," J. Cell Biol., 113(3):681-7, May, 1991.
Zhou et al., "Differential effects of transforming growth factor -beta 1 and bone morphogenetic protein 4 on gene preosteoblasts," J. Cell Physiol., 155(1):112-9, Apr., 1993.
Ashton et al., "Distribution of fibroblastic colony-forming cells in rabbit bone marrow and assay of their osteogenic potential by an in vivo diffusion chamber method," Calcif. Tissue Int., 36:83-86, 1984.
Bab et al., "Kinetics and differentiation of marrow stromal cells in diffusion chambers in vivo," J. Cell. Sci., 84:139-151, 1986.
Bleiberg, "Colony forming cell-fibroblast development in extracellular matrix-induced bone and bone marrow formation in rat," Connect. Tissue. Res., 14:121-127, 1985.
Bleiberg et al., "New bone formation and bone marrow differentiation induced in rats by extracellular bone matrix implantation: Effect of local preirradiation on the process," Ex. Hematol., 15:309-315, 1987.
Casser-Bette et al., "Bone formation by osteoblast-like cells in a three-dimensional cell culture," Calcified Tissue Int., 46:46-56, 1990.
Friedenstein et al., "Marrow microenvironment transfer by heterotopic transplantation of freshly isolated and cultured cells in porous sponges," Exp. Hematol., 10:217-227, 1982.
Friedenstein et al., "Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers," Cell Tissue Kinet., 20:263-272, 1987.
Gehron-Robey et al., "Osteoblasts synthesize and respond to transforming growth factor-type .beta. (TGF-.beta.) in vitro," J. Cell Biol., 105:457-463, 1987.
Gehron-Robey et al., "The Cellular Biology and Molecular Biochemistry of Bone Formation," In: Disorders of Bone and Mineral Metabolism, Coe & Favus, Eds., Ch. 11, 241-263, 1992.
Howlett et al., "Mineralization in in Vitro Cultures of Rabbit Marrow Stromal Cells," Clin. Orthop., 213:251-263, 1986.
Kassem et al., "Formation of osteoblast-like cells from human mononuclear bone marrow cultures," APMIS, 99:269-274, 1991.
Lian & Stein, "Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation," Crit. Rev. Oral Biol. Med., 3:269-305, 1992.
Long et al., "Characterization of Human Bone Marrow-Derived Osteoprogenitor Cells," Journal of Bone and Mineral Research, Abstract #987, 8(1):S363, 1993.
Luria et al., "Bone formation in organ cultures of bone marrow," Cell Tissue Res., 248:449-454, 1987.
Maniatopoulos et al., "Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats," Cell Tissue Res., 254:317-330, 1988.
Mardon et al., "Development of osteogenic tissue in diffusion chambers from early precursor cells in bone marrow of adult rats," Cell Tissue. Res., 250:157-165, 1987.
Marks & Popoff, "Bone cell biology: The regulation of development, structure, and function in the skeleton," Am. J. Anat., 183:1-44, 1988.
McCulloch et al., "Osteogenic progenitor cells in rat bone marrow stromal populations exhibit self-renewal in culture," Blood 77(9):1906-1911, 1991.
Muthukumaran & Reddi, "Bone matrix-induced local bone induction," Clin. Orth. Rel. Res., 200:159-164, 1985.
Owen et al., "Clonal analysis in vitro of osteogenic differentiation of marrow CFU-F," J. Cell Sci., 87:731-738, 1987.
Reddi & Cunningham, "Bone induction by osteogenin and bone morphogenetic proteins," Biomaterials, 11:33-34, 1990.
Recker, "Embryology, Anatomy, and Microstructure of Bone," In: Disorders of Bone and Mineral Metabolism, Coe & Favus, Eds., Ch. 10, 219-240, 1992.
Turksen & Aubin, "Positive and negative immunoselection for enrichment of two classes of osteoprogenitor cells," J. Cell Biol., 114:373-384, 1991.
Gronthos S., S.E. Graves, O. Ohta, and P.J. Simmons, The STRO-1.sup.+ Fraction of Adult Human Bone Marrow Contains the Osteogenic Precursors. Blood 1994; 84:4164-4173.
Long, M.W et al. (1990) Expression of Human bone-related proteins in the Hematopoietic Microenvironment. J. Clin. Invest. 86 1387-1395.
Long, M.W. et al (1988). Synergistic Regulation of Human Mega-Kamocyte Development. J. Clin. Invest. 82 1779-1786.
Simmons, D.L et al. (1992). Molecular Cloning of a CDNA Encoding CD34, a Sialomucin of Human Hematopoietic Stem Cells. J. of Immunology vol. 148 267-271.
Long Michael W.
Mann Kenneth G.
Reeves Julie
The Regents of the University of Michigan
LandOfFree
Bone precursor cells: compositions and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bone precursor cells: compositions and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bone precursor cells: compositions and methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-762922