Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2002-12-20
2008-09-16
Kam, Chih-Min (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C530S300000, C530S350000, C435S006120, C435S069100, C435S320100, C536S023500
Reexamination Certificate
active
07425531
ABSTRACT:
The present invention relates to a bone polypeptide, particularly bone polypeptide-1 and nucleic acid molecules encoding the same. The present invention provides the human primary sequence of bone polypeptide-1 as well as sequences of vertebrate homologs. The invention also provides cell lines engineered to express the cDNA, antibodies to detect its translation products, and recombinant adenoviruses to deliver an expressible cDNA into a host. Bone polypeptide-1 can be utilized to treat diseases affecting renal and bone functions.
REFERENCES:
patent: 2007/0042374 (2007-02-01), Shimomura et al.
patent: 2007/0049521 (2007-03-01), Lanctot et al.
Andréa Frota Ruchon et al., “Development Expression and Tissue Distribution of Phex Protein : Effect of the Hyp Mutation and Relationship to Bone Markers”, Journal of Bone and Mineral Research, vol. 14, No. 8, 2000, pp. 1440-1450.
Steven Henikoff et al., “Automated Assembly of Protein Blocks for Database Searching”, Nucleic Acids Research, vol. 19, No. 23, 1991, pp. 6565-6572.
Thomas P. Hopp et al., “Prediction of Protein Antigenic Determinants From Amino Acid Sequences”, Proc. Natl. Acad. Sci. USA, vol. 78, No. 6, Jun. 1981, pp. 3824-3828.
F. Francis et al., “A Gene (PEX) With Homologies to Endopeptidases is Mutated in Patients With X-Linked Hypophosphatemic Rickets”, Nature Genetics, vol. 11, Oct. 1995, pp. 130-136.
T. Inagami et al., “Biochemical Studies of Rat Atrial Natriuretic Factor”, Clin. and Exper.—Theory and Practice, A7(5 & 6), 1985, pp. 851-866.
R. Kumar, “Tumor-Induced Osteomalacia and the Regulation of Phosphate Homeostasis”, Bone, vol. 27, No. 3, Sep. 2000, pp. 333-338.
Vishwanath R. Lingappa et al., “Cell-Free Synthesis and Segregation of β2-Microglobulin”, Proc. Natl, Acad. Sci. USA, vol. 76, No. 8, Aug. 1979, pp. 3651-3655.
Nathalle Louis et al., “Cloning and Sequencing of the Cellular—Viral Junctions From the Human Adenovirus Type 5 Transformed 293 Cell Line”, Virology 233, Article No. VY978597, 1997, pp. 423-429.
Hiroshi Mayahara et al., “In Vivo Stimulation of Endosteal Bone Formation by Basic Fibroblast Growth Factor in Rats”, Growth Factors, vol. 9, 1993, pp. 73-80.
Stavros C. Manolagas, “Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis”, Endocrine Reviews 21(2), 2000, pp. 115-137.
Kazuo Maruyama et al., “Oligo-Capping: A Simple Method to Replace the Cap Structure of Eukaryotic MRNAS With Oligoribonucleotides”, Gene, 138, 1994, pp. 171,174.
Nicola C. Partridge et al., “Morphological and Biochemical Characterization of Four Clonal Osteogenic Sarcoma Cell Lines of Rat Origin”, Cancer Research, 43, Sep. 1983, pp. 4308-4314.
William R. Pearson et al., “Improved Tools for Biological Sequence Comparison”, Proc. Natl. Acad. Sci. USA, vol. 85, Apr. 1988, pp. 2444-2448.
Thierry Ragot et al., “Adenoviral Gene Delivery”, chap.11 In: “Methods in Cell Biology”, vol. 52, 1998, pp. 229-260
Andréa Frota Ruchion et al., “PEX MRNA is Localized in Developing Mouse Osteoblasts and Odontoblasts”, J. of Histochemistry & Cytochemistry, vol. 46(4), 1998, pp. 459-468.
R. G. G. Russell et al., “Biosposphonates: From the Laboratory to the Clinic and Back Again”, Bone, vol. 25, No. 1, Jul. 1999, pp. 97-106.
T. F. Smith et al., “Identification of Common Molecular Subsequences”, J. Mol. Biol., 147, 1981, pp. 195-197.
Theodore J. Tsomides et al., “Stoichiometric Labeling of Peptides by Iodination on Tyrosyl or Histidyl Residues”, Analytical Biochemistry, 210, 1993, pp. 129-135.
Wei Yan et al., “Corin, A Mosaic Transmembrane Serine Protease Encoded by a Novel CDNA From Human Heart”, J. Biol. Chem., vol. 274, No. 21, May 21, 1999, pp. 14926-14935.
Wei Yan et al., “Corin, A Transmembrane Cardiac Serine Protease, Acts as a Pro-Atrial Natriuretic Peptide-Converting Enzyme”, PNAS, vol. 97, No. 15, Jul. 18, 2000, pp. 8525-8529.
Patricia Ducy et al., “Leptin Inhibits Bone Formation Through a Hypothalamic Relay : A Central Control of Bone Mass”, Cell, vol. 100, Jan. 21, 2000, pp. 197-207.
Patricia Ducy “CBFA1 : A Molecular Switch in Osteoblast Biology”, Developmental Dynamics, 219, 2000, pp. 461-471.
Mariyln Kozak, “Point Mutations Define a Sequence Flanking the Aug Initiator Codon That Modulates Translation by Eukaryotic Ribosomes”, Cell, vol. 44, Jan. 31, 1986, pp. 283-292.
Stephen F. Altschul, “A Protein Alignment Scoring System Sensitive at All Evolutionary Distances”, J. Mol. Evol., 36, 1993, pp. 290-300.
Gillian, M. Olins, “A Linear Analog of Atrial Natriuretic Peptide (ANP) Discriminates Guanylate Cyclase-Coupled ANP Receptors From Non-Coupled Receptors”, The Journal of Biological Chemistry, vol. 263, No. 22, Aug. 5, 1988, pp. 10989-10993.
Robert M. Neer, “Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women With Osteoporosis”, N. Engl. J. Med., vol. 344, No. 19, May 10, 2001, pp. 1434-1441.
Saul B. Needleman et al., “A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins”, J. Mol. Biol., 48, 1970, pp. 443-453.
David G. Wilkinson, “Detection of Messenger RNA by in Situ Hybridization to Tissue Sections and Whole Mounts”, Methods in Enzymology, vol. 225, 1993, pp. 361-372.
R. H. Unger, “Leptin Physilology: A Second Look”, Regulatory Peptides, 92, 2000, pp. 87-95.
Samuel Karlin et al., “Methods for Assessing the Statistical Significance of Molecular Sequence Features by Using General Scoring Schemes”, Proc. Natl. Acad. Sci. USA, vol. 87, Mar. 1990, pp. 2264-2268.
Samuel Karlin et al., “Applications and Statistics for Multiple High-Scoring Segments in Molecular Sequences”, Proc. Natl. Acad. Sci. USA, vol. 90, Jun. 1993, pp. 5873-5877.
Eugene W. Myers, “An Overview of Sequence Comparison Algorithms in Molecular Biology”, Technical Report, 29, Department of Computer Science, University of Arizona, 1991, 42 p.
Bleakman, A. et al., “Sequential processing reactions in the formation of hormone amides,”Eur. J. Biochem., vol. 167, No. 1, pp. 161-165 (Aug. 17, 1987) (1 page abstract).
Office Action of Jun. 27, 2007 for U.S. Appl. No. 11/210,631 (U.S. Pat. Appl. Pub. No. 2007/0049521).
Elisabeth M. Aarden et al., “Function of Osteocytes in Bone”, Journal of Cellular Biochemistry, 55, 1994, pp. 287-299.
Cedo M. Bagi et al., “Systemic Administration of RHIGF-I or RHIGF-I/IGFBP-3 Increases Cortical Bone and Lean Body Mass in Ovariectomized Rats”, Bone, vol. 16, No. 4, 1995, pp. 263S-269S.
Roland Baron, “Anatomy and Ultrastructure of Bone”, Chap. 1 in: “Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism”, pp. 3-10, (2006).
Roger S. Birnbaum et al. “Ontogeny of Peptidyglycine Alpha-Amidating Monooxygenase Activity in Rapidly Mineralizing Bone From Neonatal Mouse”, Endocrinology, vol. 124, No. 6, 1989, pp. 3134-3136.
Piotr Chomczynski et al., “Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction”, Analytical Biochemistry, 162, 1987, pp. 156-159.
George M. Church et al., “Genomic Sequencing”, Proc. Natl. Acad. Sci. , vol. 81, Apr. 1984, pp. 1991-1995.
Jean-Bernard Denault et al., “Furin/Pace/SPC1 : A Convertase Involved in Exocytic and Endocytic Processing of Precursor Proteins”, FEBS Letters, 379, 1996, pp. 113-116.
Flanagan et al., “Alkaline Phosphatase Fusions of Ligands or Receptors as in Situ Probes for Staining of Cells, Tissues, and Embryos”,Methods in Enzymology(2000) 327:19-35.
Flanagan et al., &
Lanctot Christian
Moffatt Pierre
Salois Patrick
Dorn Brian R.
Enobia Pharma Inc.
Kam Chih-Min
Merchant & Gould P.C.
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