Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-07-29
2008-07-29
Landsman, Robert S. (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000
Reexamination Certificate
active
10286152
ABSTRACT:
The present invention provides methods and kits for diagnosing and treating glaucoma.
REFERENCES:
patent: 5145871 (1992-09-01), Cavazza
patent: 5364884 (1994-11-01), Varma et al.
patent: 6207450 (2001-03-01), Sheffield et al.
patent: 6248571 (2001-06-01), Schmidt et al.
patent: 6248867 (2001-06-01), Nguyen et al.
patent: 6613563 (2003-09-01), Sosnowski et al.
patent: WO 96/14411 (1996-05-01), None
patent: WO 98/20889 (1998-05-01), None
patent: WO 92/085909 (2002-10-01), None
Dermer, G. Bio/Technology, 12: 320, 1994.
Jain, R. Cancer and Metastasis Reviews, 9: 253-266, 1990.
Gutteridge, Clinical and Exp. Optometry, vol. 83, 161-172, 2000.
Strachan, Tom and Read, Andrew P., “Molecular Pathology”, Human Molecular Genetics, Chapter 15, pp. 401-426 (1996).
Agarwal R, et al., “FAS-activated apoptosis and other apoptosis mediators in human trabecular meshwork cells,” Exp. Eye Res. 68:583-590 (1999).
Astrom, A.K., et al., “Chromosomal localization of three human genes endcoding bone morphogenetic protein receptors”, Mammalian Genome 10(3):299-302 (1999).
Attisano L, Tuen Lee-Hoeflich S, “The Smads,” Genome Biol. 2(8) Reviews/3010.1 (2001) 1-8.
Bengtsson B, “Incidence of manifest glaucoma,” BR J Ophthalmol, 73:483-487 (1989).
Birren, et al., Genome Analysis, A Laboratory Manual vol. 2 Detecting Genes, (Bruce Birren ed., Cold Spring Harbor Laboratory Press 1998) 287-292.
Chang et al., “Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure”, BioMed Central, BMC Genetics, 2:18 (2001).
Clark AF, et al., “Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells,” Invest. Ophthalmol. & Vis. Sci. 35(1):281-294 (1994).
Clark AF, et al., “Cell biology of the human lamina cribrosa,” In Drance SM (ed). Optic Nerve In Glaucoma. Kugler Publications, New York: pp. 79-105 (1995).
Clark AF, et al., “Cytoskeletal changes in cultured human glaucoma trabecular meshwork cells,” J. Glaucoma 4:183-188 (1995).
Clark AF, et al., “Dexamethasone-Induced ocular hypertension in perfusion-cultured human eyes,” Invest. Ophthalmol. & Vis. Sci. 36(2):478-489 (1995).
Clark AF, et al., “Inhibition of dexamethasone-induced cytoskeletal changes in cultured human trabecular meshwork cells by tetrahydrocortisol,” Invest. Ophthalmol. & Vis. Sci. 37(5):805-813 (1996).
Clark AF, et al., “Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head,” FASEB J. 15:1251-1253 (2001).
Clark AF, et al., “Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues,” Invest. Ophthalmol. & Vis. Sci. 42(8):1769-1780 (2001).
Cummings, Michael R., Human Heredity, Fourth Edition, (West/Wadsworth 1997) 266-283.
Dickerson JE, et al., “The effect of dexamethasone on integrin and laminin expression in cultured human trabecular meshwork cells,” Exp. Eye Res. 66:731-738 (1998).
Dudley et al., “A requirement for bone morphogenic protein-7 during development of the mammalian kidney and eye,” Genes & Development 9:2795-2807 (1995).
Elbashir SM, et al., “Duplexes of 21-nucleodide RNAs mediate RNA interference in cultured mammalian cells”, Nature 411:494-498, 2001.
Encio et al., “The Genomic Structure Of The Human Glucocorticoid Receptor”, J. Biol. Chem. 266(11):7182-7188 (1991).
Furuta and Hogan, “BMP4 is essential for lens Induction in the mouse embryo,” Genes & Dev. 12:3764-3775 (1998).
Giguère et al., “Functional Domains of the Human Glucocorticoid Receptor”, Cell 46:645-652 (1986).
Greve, M. et al., “Comparison of the oculokinetic perimetry glaucoma screener with two types of visual filed analyser”, Can. J. Ophthamol. 28(5):201-206 (1993).
Grierson I et al., “Characteristics of Meshwork Cells and Age Changes in the Outflow System of the Eye: Their Relevance to Primary Open Angle Glaucoma.” In Mills KB (ed). Glaucoma. Proceedings of the Fourth International Symposium Of The Northern Eye Institute, Manchester, UK, New York, Pergamon: pp. 12-31 (1988).
Hernandez, et al., “Changes in the Extracellular Matrix of the Human Optic Nerve Head in Primary Open-Angle Glaucoma,” Am. J. Ophthalmol. 109:180-188 (1990).
Hernandez M and Gong H, “Extracellular matrix of the trabecular meshwork and optic nerve head.” in Ritch R., Shields, M.B., Krupin, T. (eds). The Glaucomas, 2nd ed. St Louis: Mosby-Year; pp. 213-249 (1996).
Hernandez MR and Pena JD, “The optic nerve head in glaucomatous optic neuropathy,” Arch Ophthalmol. 115:389-395 (1997).
Hitchings RA, “Glaucoma screening”, Br. J. Ophthamol. 77:326 (1993).
Hogan BL, “Bone morphogenic proteins: multifunctional regulators of vertebrate development,” Genes Dev. 10:1580-1594 (1996).
Hollenberg et al., “Primary Structure And Expression Of A Functional Human Glucocorticoid Receptor cDNA”, Nature 318(19):635-641 (1985).
Hu and Ritch, “Hepatocyte Growth Factor is Increased in the Aqueous Humor of Glaucomatous Eyes,” J. Glaucoma 10:152-157 (2001).
Inatani et al., “Transforming growth factor β2 levels in aqueous humor of glaucomatous eyes,” Graefes Arch. Clin. Exp. Ophthalmol. 239:109-113 (2001).
Itoh et al., “Signaling of transforming growth factor-β family members through Smad proteins”, Eur. J. Biochem. 267:6954-6967 (2000).
Jacobson N, et al., “Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor,” Human Molecular Genetics 10(2):117-125 (2001).
Jena et al., “BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye,” Exp. Cell Res. 230:28-37 (1997).
Jorde, et al., Medical Genetics, Second Edition, (Mosby 1999) 29-57.
Kawabata et al., “Signal Transduction by Bone Morphogenetic Proteins” Cytokine & Growth Factor Reviews, vol. 9, No. 1, 49-61 (1998).
Kerrigan et al., “Tunel-positive ganglion cells in human primary open-angle glaucoma,” Arch. Ophthalmol. 115:1031-1035 (1997).
Lambert W, et al., “Neurotrophin and neurotrophin receptor expression by cells from the human lamina cribrosa,” Invest. Ophthalmol. Vis. Sci., 42(10):2315-2323 (2001).
Leske MC, et al., “The Epidemiology Of Open-Angle Glaucoma: A Review”, American Journal Of Epidemilogy, 118(2):166-191 (1983).
Liu X, et al. “Human trabecular meshwork cells express the ciliary neurotrophic factor (CNTF) tripartate receptor complex,” Exp. Eye Res. 72:711-717 (2001).
Liu Y, et al., “The effect of bone morphogenic protein-7 (BMP07) on functional recovery, local cerebral glucose utilization and blood flow after transient focal cerebral ischemia in rats,” Brain Res. 905;81-90 (2001).
Luo et al. , “BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning,” Genes & Development 9:2808-2820 (1995).
Lütjen-Drecoll E. and Rohen J.W., “Morphology of aqueous outflow pathways in normal and glaucomatous eyes,” in Ritch R., Shields, M.B., Krupin, T. (eds). The Glaucomas, 2nd ed. St Louis: Mosby-Year; pp. 89-123 (1996).
McMahon R., et al., “IHG-2, a Mesangial Cell Gene Induced by High Glucose, Is Human gremlin”, J. Biol. Chem. 275(14):9901-9904 (2000).
Miyazono, “Positive and negative regulation of TGF-b signaling”, J. Cell Science, 113:1101-1109 (2000).
Mohan, et al., “Bone morphogenic proteins 2 and 4 and their receptors in the adults human cornea,” Invest. Ophthalmol. & Vis. Sci. 39(13):2626-2636 (1998).
Morrison JC, et al., “Optic nerve head extracellular matrix in primary optic atrophy and experimental glauco
Clark Abbot F.
Wordinger Robert J.
Alcon Inc.
Chandra Gyan
Derry Jason J.
Landsman Robert S.
University of North Texas Health Science Center
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