Bone morphogenetic protein 4 and osteogenic devices and...

Details Bone morphogenetic protein 4 and osteogenic devices and... Bone morphogenetic protein 4 and osteogenic devices and...

2006-05-26

2010-10-05

Kemmerer, Elizabeth C. (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C530S351000, C530S300000, C435S320100, C435S325000, C435S252300, C435S254110, C435S069700, C536S023100, C536S023400, C536S023500

Reexamination Certificate

active

07807627

ABSTRACT:
The present invention relates to reindeer bone formation inducing protein called bone morphogenetic protein 4 (BMP-4) and nucleotide molecules encoding the proteins and host cells expressing the proteins. The present invention relates also to the use of the BMP-4 for treating disorders related to bone and cartilage formation. Osteogenic devices and pharmaceutical compositions containing the proteins are also disclosed.

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Ngo et al., 1994, The Protein Folding Problem and Tertiary Structure Prediction, Merz et al., eds., Birkhauser, Boston, pp. 492-495.
Extended European Search Report dated Feb. 27, 2009.
Jian Q. Feng et al., “Deer antler tissue contains two types of bone morphogenetic protein 4 mRNA transcripts”, Biochemica et Biophysica Acta, 1995, pp. 163-168, vol. 1263, No. 2, Elsevier Science B.V.
Database UNIPROT [Online} Feb. 15, 2005 “Bone Morphogenetic Protein 4” (Fragment, Bros Taurus) Retrieved From INIPROT/EBI Database Accession No. Q51419, See Amino Acids 274-389.
Database UNIPROT[Online] Nov. 1, 1997 “Bone Morphogenetic Protein 4 Precursor” (Dama Dama) Retrieved From UNIPROT/EBI, Database Accession No. Q29607, See Amino Acids 293-408.

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