Bone morphogenetic protein

Details Bone morphogenetic protein Bone morphogenetic protein

1981-05-05

1984-06-19

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260118, 2601237, 424 95, 424177, C07G 700

Patent

active

044552564

ABSTRACT:
Bone morphogenetic protein (BMP) made by the process comprising the steps of demineralizing bone tissue; treating the demineralized bone tissue under aqueous conditions with a water soluble neutral salt and a solubilizing agent for the BMP, the agent being selected from the group consisting of urea and guanidine, and thereby transforming the bone collagen to gelatin and extracting BMP into the solution of solubilizing agent; and separating the solubilizing agent and neutral salt from the solution, thereby precipitating BMP in the aqueous medium, and the BMP has a molecular weight in the range of 1,000-100,000.

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patent: 4294753 (1981-10-01), Urist
Lancet, May 2, 1981, pp. 959-962, Glowacki et al.
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Proc. Soc. Exptl. Biology & Med., 162:48-53, (1979), Urist et al.
Urist et al., 15 (4), 269-286, (1974), Calcified Tissue Research.
Urist et al., Clin. Orthop. Rel. Res. 53,243-283, (1967).
Urist et al., Proc. Soc. Exp. Bio. and Med. 162, 48-53, (1979).
Urist et al., Proc. Natl. Acad. Sci. USA 76 (4), 1828-1832, Apr. 1979.

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