Surgery – Miscellaneous – Methods
Patent
1994-11-02
1998-09-15
Lacyk, John P.
Surgery
Miscellaneous
Methods
A61B 1900
Patent
active
058065296
ABSTRACT:
The present invention provides a method for bone marrow transplantation from an HLA-nonmatched donor to a patient which comprises conditioning the patient under a suitable regimen followed by transplant of a very large dose of stem cells which is at least about 3-fold greater than the conventional doses used in T cell-depleted bone marrow transplantation. The patient is conditioned under lethal or supralethal conditions for the treatment of malignant or non-malignant diseases, or under sublethal conditions for the treatment of non-malignant diseases. The transplant may consist of T cell-depleted bone marrow stem cells and T cell-depleted stem cell-enriched peripheral blood cells from the HLA-nonmatched donor. preferably a relative of the patient, which donor was previously treated with a drug, e.g. a cytokine such as granulocyte colony-stimulating factor (G-CSF).
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Martelli Massimo
Reisner Yair
Lacyk John P.
Yeda Research and Development Co. Ltd.
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