Bone marrow suppressing agents

Details Bone marrow suppressing agents Bone marrow suppressing agents

1989-11-13

1990-12-11

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, 252625, A61K 4300, C07F 500

Patent

active

049769502

ABSTRACT:
The invention concerns a method for suppressing bone marrow which comprises administering to a mammal at least one bone marrow suppressing complex of a radionuclide selected from the group consisting of Samarium-153, Gadolinium-159, Holmium-166 and Yttrium-90 and at least one macrocyclic aminophosphonic acid ligand containing the 1,4,7,10-tetraazacyclododecane moiety, or a physiologically acceptable salt thereof. Suitable compositions for use in this method are also provided.

REFERENCES:
patent: 4508625 (1985-04-01), Graham
patent: 4678667 (1987-07-01), Meares et al.
patent: 4853209 (1989-08-01), Kaplan et al.
patent: 4882142 (1989-11-01), Simon et al.
patent: 4898724 (1990-02-01), Simon et al.
Keeling, A. A. et al., "A Bone Seeking Radiotherapeutic Agent," Journal Nucl Medicine, vol. 30, No. 5, May 1989.

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