Bone marrow suppressing agents

Details Bone marrow suppressing agents Bone marrow suppressing agents

1987-10-27

1989-08-01

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, A61K 4300, C07F 1700

Patent

active

048532096

ABSTRACT:
The invention concerns a method for suppressing bone marrow which comprises administering at least one bone marrow suppressing radionuclide composition selected from the group of radionuclide compositions comprised of at least one of Samarium-153, Gadolinium-519, and Holmium-166 and at least one of ethylenediaminetetramethylenephosphonic acid, diethylenetriaminepentamethylenephosphonic acid, hydroxyethylethylenediaminetrimethylenephosphonic acid, nitrilotrimethylenephosphonic acid and tris(2-aminoethyl)aminehexamethylenephosphonic acid, or a physiologically acceptable salt thereof.

REFERENCES:
patent: 3965254 (1976-06-01), Tofe et al.
patent: 4017595 (1977-04-01), Subramanian et al.
patent: 4054645 (1977-10-01), Hill et al.
patent: 4232000 (1980-11-01), Fawzi
patent: 4385046 (1983-05-01), Milbrath et al.
Subramanian et al., J. Nucl. Med. 16(11), 1080-1084 (1975).
Rosoff et al., "Distribution and Excretion of Radioactive Rare-Earth Compounds in Mice", Int. J. Applied Rad. and Isotopes, 14, 129-135 (1963).

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