Bone inducing agent from a human osteosarcoma cell line

Details Bone inducing agent from a human osteosarcoma cell line Bone inducing agent from a human osteosarcoma cell line

1987-10-09

1991-07-30

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Tissue, other than lymphoid tissue

4352402, A61K 3512, C12N 508

Patent

active

050359010

ABSTRACT:
Human osteosarcoma Saos-2 cell extracts as for example in the form of a killed-cell, defatted cell residue are found to retain bone inducing-agent(s) after freeze-drying. Pellets of this material were found to promote new bone formation. This material is useful therefore for healing bone defects, bone tumors, bone fractures and in promoting bone graft assimilation.

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Anderson and Coulter, "Bone inducing capability of cultured human cells (FL) and Hela compared to that of various types of injury" Fed. Proc., 27:475 (1968).
Anderson, "Epithelial-mesenchyrmal cell interactions" Clin. Orthop., 119:211-224.

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