Bone graft substitute and its preparation

Details Bone graft substitute and its preparation Bone graft substitute and its preparation

1998-06-08

2001-05-15

Milano, Michael J. (Department: 3738)

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Bone

Reexamination Certificate

active

06231607

ABSTRACT:

FIELD OF THE INVENTION
The present invention relates to the preparation of artificial bone or bone graft substitutes. In particular, it relates to hydroxyapatite ceramics which are suitable for this purpose.
BACKGROUND OF THE INVENTION
There are many advantages in using bone graft substitutes over transplantable allografts which include avoidance of the danger of transmitting infectious diseases to the host, they are less expensive and are more readily available. However, the mechanical strength of available substitutes is substantially lower than allografts, they lack elasticity and exhibit a poor osteoinductive capability.
During the last two decades porous, calcium and phosphate-based ceramics were developed as synthetic bone graft substitutes. Past works have shown that these substitutes are biocompatible and are easily fabricated in a variety of sizes and shapes. These ceramic compositions of matter typically comprise hydroxyapatite (hereinafter: “HA”) and tricalcium phosphate (hereinafter: “TCP”) or a mixture (hereinafter: “HA+TCP”) thereof.
Synthetic apatites mixed with tricalcium phosphate are widely used in bones and teeth transplantation. Following preparations, the HA+TCP is usually subjected to a mechanical treatment in which the material is ground and/or pressed to obtain a required porosity, hardness or shape, partially overcoming the problems associated with the bone graft substitutes discussed above.
However, the requirement to obtain a good quality bone graft substitute still exists, as well as the need to simplify the mechanical treatment stage.
It is an object of the present invention to provide a bone substitute being suitable for use as a transplantable graft.
It is a further object of the invention to provide a process for preparing such a bone substitute.
Other objects of the invention will become apparent from the following description.
SUMMARY OF THE INVENTION
In accordance with the invention a novel process for the preparation of a composition of matter useful as a bone graft substitute has been developed. The novel process which constitutes one facet of the invention, yields a composition of matter, which is novel per se, and which constitutes another facet thereof. For reasons which are not yet fully elucidated, the novel composition of matter of the invention possesses improved properties in its use as a bone graft substitute.
The present invention provides, by a first of its aspects, a composition of matter useful as a bone graft substitute. The composition of matter of the invention comprises a mixture of tricalcium phosphate (TCP) and crystallized hydroxy apatite (HA) and is a solid mass typically formed so as to be suitable for transplantation. The composition of matter of the invention is unique in that rather than having essentially only the &bgr; form of TCP (&bgr;-TCP), it comprises both &agr;- and &bgr;- TCP.


REFERENCES:
patent: 4861733 (1989-08-01), White
patent: 5084051 (1992-01-01), Tormala et al.
patent: 5152836 (1992-10-01), Hirano et al.
patent: 5747390 (1998-05-01), Cooper et al.
patent: 5885540 (1999-03-01), Fulmer et al.
patent: 3925185 (1990-05-01), None
patent: 0705802 (1996-04-01), None
patent: 0705802 (1996-10-01), None
patent: 9523775 (1995-09-01), None

Affiliated with

Also associated with

Rating

Bone graft substitute and its preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bone graft substitute and its preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bone graft substitute and its preparation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2542172