Bone graft material for osseous defects and method of making sam

Details Bone graft material for osseous defects and method of making sam Bone graft material for osseous defects and method of making sam

1981-09-21

1983-07-19

Morris, Theodore

Drug, bio-affecting and body treating compositions

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Taste or smell or chemical irritation to the eye, nose, or...

106161, 106122, 2601237, 424 95, A61K 900, A61K 3532

Patent

active

043943705

ABSTRACT:
Complexes of reconstituted collagen and demineralized bone particles or reconstituted collagen and a solubilized bone morphogenetic protein fabricated in a sponge suitable for in vivo implantation in osseous defects are disclosed. Both demineralized bone particles (DBP) and bone morphogenetic protein have demonstrated the ability to induce the formation of osseous tissue in animal and human experiments. Reconstituted collagen conjugate is highly biocapatible and can be fabricated in a variety of configurations, especially as a sponge. This material can be used as a grafting implant in plastic and reconstructive surgery, periodontal bone grafting, and in endodontic procedures. Structural durability is enhanced by cross-linking with glutaraldehyde which is also used to sterilize and disinfect the collagen conjugate prior to implantation.

REFERENCES:
patent: 3767437 (1973-10-01), Cruz
patent: 3843446 (1974-10-01), Vieth et al.
patent: 3892648 (1975-07-01), Phillips et al.
patent: 3919773 (1975-11-01), Freeman
patent: 4038703 (1977-08-01), Bokros
patent: 4066083 (1978-01-01), Ries
patent: 4193813 (1980-03-01), Chvapil
patent: 4294753 (1982-10-01), Urist
Ray, R. D. et al.: Bone Joint Sur., 39A: 1119-1128, 1957.
Glowacki et al.: Calcif. Tissue Int., 33: 71-76, 1981.
Mulliken et al.: Plast. Reconstr. Surg., 65: 553-559, 1980.
Glowacki et al.: Lancet, 2 May, 1981, 963-966.
Urist, M. R. et al.: Perspect. Biol. Med., 22: 2 part, 2 S 89-S 113, 1979.
Ehrman, R. L. et al., J. Nat. Can. Inst., 16: 1375-1390, 1956.
Klebe, R. J.,: Nature, 250: 248-251, 1974.
Chvapil, M., et al.: International Review of Connective Tissue Research, vol. 6, pp. 1-55, 1973.
Jefferies, S., et al.: Journal of Biomedical Materials Research, vol. 12, 491-503, 1978.
Huggins, C. B.: Arch. Surg., 22: 377-408, 1931.
Urist, M. R., Science, 150: 893-899, 1965.
Reddi, A. H. et al.: Proc. Natl. Acad. Sci., USA 69: 1601-1605, 1972.
Reddi, A. H. et al.: Proc. Natl. Acad. Sci., USA 71: 1648-1652, 1974.
Urist, M. R., Mikulski, A., Lietz, Al.: Proc. Natl. Acad. Sci., USA: 76: 1828-1932, 1979.
Narang, R., et al.: Oral Sur., 35, 136-143, 1973.

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