Food or edible material: processes – compositions – and products – Fermentation processes – Of milk or milk product
Patent
1994-01-24
1997-08-05
Lilling, Herbert J.
Food or edible material: processes, compositions, and products
Fermentation processes
Of milk or milk product
424535, 514 2, 426590, 426800, 426807, A61K 3802, A61K 3520, A61K 3800
Patent
active
056540191
DESCRIPTION:
BRIEF SUMMARY
1. FIELD OF THE INVENTION
This invention relates to an osteoblast growth and bone enhancing factor(s) derived from whey. Further, this invention relates to a bone enhancing factor(s) and foods containing the factor(s). Foods, feeds and medicines containing the factor(s) make bones of human who takes them strong and are useful for preventing or treating maladies in joints of bones and osteoporosis.
2. BACKGROUND OF THE INVENTION
Recently, the number of patients suffering from bone maladies such as osteoporosis, fracture and lumbago is increasing in proportion to increase of aged people. These bone maladies are mainly caused by lack of calcium intake, lowering of calcium absorbing ability, lack of secretion of active vitamin D.sub.3, unbalance of hormones relating calcium metabolism and the like and the main causes are made clear as follows.
In bone tissues, bones are always destroyed, resorbed and created. At young ages, the bone resorption and formation are balanced, but the bone resorbing activity in the bone tissues becomes higher than the bone creating activity in proportion to aging (hereinafter called uncoupling) by various causes. When the uncoupling continues for a long time, the bone tissues become brittle and the above mentioned maladies are caused. Therefore, it is considered that the osteoporosis, fracture and lumbago can be prevented by preventing the uncoupling.
As treatments and prevention against the maladies in joints of bones and osteoporosis by preventing the uncoupling, (1) sufficient calcium supply by foods, (2) light exercises, (3) sun tan and (4) medical treatments have been performed in past.
For the calcium supply by foods, calcium salts such as calcium carbonate, calcium lactate, calcium phosphate and the like and natural calcium materials such as bovine bone powder, egg shell powder, fish bone powder and the like are used. However, some of these calcium salts become water insoluble in digestive organs and cannot be absorbed from intestines and absorbed calcium is not always used for bone formation, if bone creating activities are low.
For the light exercises, a light walk for around 30 minutes or the like is considered to be recommendable. However, as a body becomes weak, it becomes hard to do light exercises. Furthermore, it is almost impossible to do exercises for aged people who cannot even get up from a bed.
Sunlight promotes the biosynthesis of vitamin D.sub.3 in the human body, but the supply of vitamin D.sub.3 is not enough to prevent the uncoupling and to prevent maladies in joints of bones and osteoporosis.
For the medical treatments, medicines such as 1.alpha.-hydroxyvitamin D.sub.3, calcitonin and the like are popularly known for bone enhancing ability themselves. However, these medicines consist of chemical compounds as effective components and are not food materials which can enhance bones by being taken safely in a mild condition for a long time.
As mentioned above, the food materials taken safely in a mild condition for a long time to enhance bones, whose effect is proved and established, are not known yet.
3. DISCLOSURE OF THE INVENTION
Milk is well known as a safe food to be taken for a long time and to enhance bones. The present inventors took notice of this nature of milk, assumed that there would be a factor(s) to enhance bones in milk, particularly whey and have been studying about the bone enhancing factor(s) in whey proteins. That is, the inventors have been trying to fractionate a protein fraction in milk, particularly whey and to extract a fraction having osteoblast growth and bone enhancing ability from the protein fraction. Consequently, the inventors found that a mixture of proteins and peptides obtained by treating a water soluble fraction of whey proteins with reverse osmosis (RO), electrodialysis (ED) or the like to remove salts contained in whey proteins had bone enhancing ability and applied the invention as Japanese Patent Application HEI 2-309504.
The inventors have been carrying out the fractionation of such whey proteins, found that the
REFERENCES:
patent: 4089987 (1978-05-01), Chang
patent: 4143174 (1979-03-01), Shah et al.
patent: 4209503 (1980-06-01), Shah et al.
patent: 5028436 (1991-07-01), Gauri
Derwent ABS 92-265574/32 JP04183371 Jun. 30, 1992.
Kobayashi Naomichi
Takada Yukihiro
Yahiro Masatoshi
Lilling Herbert J.
Snow Brand Milk Products Co. Ltd.
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