Bone collagen matrix for zenogenic implants

Details Bone collagen matrix for zenogenic implants Bone collagen matrix for zenogenic implants

1989-10-17

1990-12-04

Nutter, Nathan M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530356, 530402, 530412, 530427, 530840, 128DIG8, 424423, 424424, 424426, 523113, A61K 3712, C07K 1300, A61F 200

Patent

active

049755269

ABSTRACT:
Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen, xenogenic to the host, and biodegradable therewithin. The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its surface area and porosity. The matrix may be combined with osteogenic protein to induce reliably and reproducibly endochondral bone formation. It also can be used as a surface coat around implantable prosthetic devices to promote cellular ingrowth or as a carrier for sustained release of various therapeutic compositions.

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