Bone collagen matrix for xenogenic implants

Details Bone collagen matrix for xenogenic implants Bone collagen matrix for xenogenic implants

1990-11-21

1992-11-10

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424424, 424426, 523113, 128DIG8, A61K 3712, A61F 200, C07K 1300, C12P 2100

Patent

active

051621142

ABSTRACT:
Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen, xenogenic to the host, and biodegradable therewithin. The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its surface area and porosity. The matrix may be combined with osteogenic protein to induce reliably and reproducibly endochondral bone formation. It also can be used as a surface coat around implantable prosthetic devices to promote cellular ingrowth or as a carrier for sustained release of various therapeutic compositions.

REFERENCES:
patent: 4172128 (1979-10-01), Thiele et al.
patent: 4394370 (1983-07-01), Jeffries
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563489 (1986-01-01), Urist
patent: 4725671 (1988-02-01), Chu et al.
patent: 4789663 (1988-12-01), Wallace et al.
patent: 4795467 (1989-01-01), Piez et al.
patent: 4812120 (1989-03-01), Flanagan et al.
Reddi, "Cell Biology and Biochemistry of Endochondral Bone", Coll. Res., vol. 1:209-226.
Sampath et al., Proc. Natl. Acad. Sci. USA, vol. 78, No. 12, pp. 7599-7603, "Dissociative Extraction and Reconstitution . . . ".
Sampath et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 6591-6595, "Homology of Bone-inductive Proteins from Human, Monkey, Bovine . . . ".
Deatherage et al., Collagen Rel. Res., vol. 7/1987, pp. 225-231, "Packaging and Delivery of Bone Induction . . . ".
Deatherage et al., Int. J. Oral Maxillofac. Surg., vol. 17/1988, pp. 395-399, "A Review of Matrix-Induced Osteogenesis . . . ".
Spector, J. Arthroplasty, vol. 2/1987, pp. 163-177, "Historical Review of Porous-coated Implants".
Strand et al., Biotech. Bioeng., vol. 26/1984, pp. 503-507, "A Modified Matrix Perfusion . . . ".
Aspenberg et al., J. Bone Joint Surg., vol. 70/1988, pp. 625-627, "Hydroxyapatite-Coated . . . ".
Glowacki et al., The Lancet, 1981, pp. 959-963, "Application of the Biological Principle of Induced . . . ".
Urist et al., Clin. Orthoped. Rel. Res., vol. 187/1984, pp. 277-280, ".beta.-tricalcium Phosphate Delivery System . . . ".
Cook et al., Clin. Orthoped. Rel. Res. vol. 232/1988 pp. 225-243 "Hydroxyapatite-Coated Titanium . . . ".

Affiliated with

Also associated with

Rating

Bone collagen matrix for xenogenic implants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bone collagen matrix for xenogenic implants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bone collagen matrix for xenogenic implants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2291136