Bone collagen matrix for implants

Details Bone collagen matrix for implants Bone collagen matrix for implants

1990-02-22

1992-12-15

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424424, 424426, 523113, 530356, 530840, 128DIG8, A61F 202, C08J 312, C08L 8904, C07K 328

Patent

active

051715740

ABSTRACT:
A matrix for implantation in a mammalian host comprising biocompatible, mineral-free, insoluble Type-I bone collagen which may be allogenic or xenogenic to the host, and which, when implanted in the host, is biodegradable. The collagen is treated with a collagen fibril modifying substance such as acidified acetonitrile, chloroform, or dichloromethane, or by heating in an aqueous environment to a temperature of 37.degree.-65.degree. C. The treated material undergoes a change in morphology involving a significant increase in its surface area as measured by various methods. Under the scanning electron microscope the material has an "oyster shell" appearance with many pits and micropores.

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