Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-05-04
1997-06-03
Walsh, Stephen G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 698, 4352542, 4353201, 536 235, 536 2351, 536 2431, C12N 1518, C12N 1581
Patent
active
056353740
ABSTRACT:
The isolation, identification and production by recombinant methods of bone calcification factor, a 22 KD polypeptide, are disclosed. The peptide has calcification-inducing activity when implanted with matrix Gla protein into mammals.
REFERENCES:
patent: 4294753 (1981-10-01), Urist
patent: 4394370 (1983-07-01), Jefferies
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4455256 (1984-06-01), Urist
patent: 4526909 (1985-07-01), Urist
patent: 4563489 (1986-01-01), Urist
patent: 4596574 (1986-06-01), Urist
patent: 4619989 (1986-10-01), Urist
patent: 4627982 (1986-12-01), Seyedin et al.
patent: 4761471 (1988-08-01), Urist
patent: 4795804 (1989-01-01), Urist
patent: 4804744 (1989-02-01), Sen
patent: 4810691 (1989-03-01), Seyedin et al.
Price et al., "Characteriztion of .gamma.-carboxyglutamic acid-containing protein From Bone," Proc. Natl. Acad. Sci. USA (1976), 73:1447-1451.
Price et al., "Matrix Gla Protein, A New .gamma.-carboxyglutamic Acid-Containing Protein which is Associated with the Organic Matrix of Bone," Biochem. Biophys. Res. Comm. (1983), 117:765-771.
Price et al., "Primary Structure of Bovine Matrix Gla Protein, A New Vitamin K-Dependent Bone Protein," J. Biol. Chem. (1985), 260:14971-14975.
Price et al., "Molecular Cloning of Matrix Gla protein: Implications for Substrate Recognition by the Vitamin K-Dependent .gamma.-Dependent .gamma.-carboxylase," Proc. Natl. Acad. Sci. USA (1987), 84:8335-8339.
Kiefer et al., "The cDNA and Derived Amino Acid Sequences for Human and Bovine Matrix Gla Protein," Nucl. Acids Res. (1988), 16:5213-5214.
Urist, "Bone: Formation by Autoinduction," Science (1965), 150:893-899.
Urist, "A bone matrix calcification-initiator noncollagenous protein," Am. J. Physiol. (1977), 232:C115-C127.
Bauer et al., "Human Osteosarcoma-Dervied Soluble Bone Morphogenetic Protein," Clin. Ortho. (1981), 154:291-295.
Conover et al., "Dentin Matrix Bone Morphogenetic Protein," ed. by Arthur Vels in Chem. Biol. Min. Corr. Tissue, (1981), pp. 597-606.
Urist et al., "A bovine low Molecular Weight Bone Morphogenetic Protein (BMP) Fraction," Clin. Ortho. (1981), 162:219-232.
Urist et al., "Bone Cell Differentiation and Growth Factors," Science, (1983), 220:680-686.
Urist et al., "Human Bone Morphogenetic Protein," Proc. Soc. Exp. Biol. Med. (1983), 173:194-199.
Sato et al., "Bone Morphogenetic Protein-induced Cartilage Development in Tissue Culture," Clin. Ortho. (1984), 183:180-187.
Urist et al., "Purification of bovine bone morphogenetic Protein by Hydroxyapatite Chromatography," Proc. Natl. Acad. Sci. USA (1984), 81:371-375.
Urist et al., "Preparation and Bioassy of Bone Morphogenetic Protein and Polypeptide Fragments," Barnes and Sirbaska, eds. in Meth. Enzymol. (1987), 146:294-312.
Kawamura et al., "Growth Factors, Mitogens, Cytokines, and Bone Morphogenetic Protein in Induced Chondrogenesis in Tissue Culture," Develop. Biol. (1988), 130:435-442.
Kawai et al., "Quantitative Computation of Induced Heterotopic Bone Formation by an Image Analysis System," Clin. Ortho. (1988), 233:262-267.
Termine et al., "Mineral and Collagen-binding Proteins of Fetal Calf Bone," J. Biol. Chem. (1981), 256:10403-10408.
Luyten et al., "Purification and Partial Amino Acid Sequence of Osteogenin, a Protein Initiating Bone Differentiation" J. Biol. Chem. (1989) 264:13377-13380.
Wozney et al., "Novel Regulators of Bone Formation: Molecular Clones and Activities," Science (1988), 242:1528-1534.
Neame et al., J. Biol. Chem. 264(10)L5474-5479 (1989).
Sambrook et al, p. 16.3 in Molecular Cloning (1989).
Lathe "Synthetic Oligonucleotides Probes . . . " J. Mol. Biol. 183:1-12 (1985).
Huynh et al "Constructing and Screening cDNA Libraries . . . " pp. 49-78 in DNA Cloning (1985).
Superti-Furga et al, "Complementary DNA Sequence and Chromosomal Mapping . . . " Genomics 17:463-467 (1993).
Cousen, L.S. et al., Gene, 61:265-275, 1987.
Cunningham, B.A. et al., Biochemistry, 12(24):4811-4822, 1983.
Maniatis, T. et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, New York, 1982.
Barr Philip J.
Kiefer Michael C.
Masiarz Frank R.
Blackburn Robert P.
Chiron Corporation
Collins Amy L.
Simboli Paul B.
Walsh Stephen G.
LandOfFree
Bone calcification factor and recombinant production of the fact does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bone calcification factor and recombinant production of the fact, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bone calcification factor and recombinant production of the fact will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-390722