Bone augmentation material

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.

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Details

514 12, 514 21, A61K 3712, C07K 1400, C08H 106, C08L 8900

Patent

active

057392862

ABSTRACT:
There is disclosed a process for the mineralization of collagen fibers whereby collagen fibers formed from collagen are contacted with a solution of calcium and phosphate ions under conditions to effect nucleation and in-vitro growth of mineral crystals within and on the surface of the collagen fibers to form intact collagen fibers with subfibrillar substructure and wherein preparations of such mineralized collagen fibers are used in bone replacement therapy as well as to induce repair in bony defects.

REFERENCES:
patent: 3443261 (1969-05-01), Battista et al.
patent: 4776890 (1988-10-01), Cho
patent: 5047031 (1991-09-01), Constanz et al.
patent: 5231169 (1993-07-01), Constanz et al.
patent: 5532217 (1996-07-01), Silver et al.

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