Bone allograft material and method

Details Bone allograft material and method Bone allograft material and method

1989-11-16

1992-05-12

Isabella, David J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Bone

A61F 228

Patent

active

051123541

ABSTRACT:
A textured, demineralized, and unitary mammalian bone section for providing a rigid, foraminous, collagen scaffold for allogenic skeletal reconstruction. The allograft is prepared by treating a section of cadaver bone to remove all soft tissue, then texturing the bone surface to produce a pattern of holes of selected size, density, and depth, and finally demineralizing the bone section to leave a rigid, insoluble collagen scaffold suitable for osteoinduction upon implantation. All such steps are performed with minimal denaturing of the extracellular matrix proteins which remain bound to the collagen scaffold and which are necessary to complete the process of new bone formation.

REFERENCES:
patent: 4277238 (1981-07-01), Katagiri
patent: 4627853 (1986-12-01), Campbell et al.
patent: 4932973 (1990-06-01), Gendler
patent: 4946792 (1990-08-01), O'Leary
Knapp et al, Use of Cortical Cancellous Allograft etc., Clin. Orthop., vol. 229, p. 98 (1988).
Glowacki et al, Application of the Biological Principle etc., Lancet, vol. 2, p. 959 (1981).
Gendler, Perforated Demineralized Bone Matrix: A New Form etc., J. of Biomed. Mat. Res., vol. 20, p. 687 (1986).
Mulliken et al, Induced Osteogenesis--The Biological Principle etc., J. of Surg. Res., vol. 37, p. 487 (1984).
Urist, Surface Decalcified Allogenic Bone Implants etc., Clin. Orthop., vol. 546, p. 37 (1968).

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