Bombesin-related peptides

Details Bombesin-related peptides Bombesin-related peptides

1994-02-25

1995-04-25

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

514 14, 514 15, 530327, 530328, A61K 3700, A61K 31445, A01N 4340

Patent

active

054100186

ABSTRACT:
A pure DNA encoding a peptide which encodes a novel bombesin-related peptide, i.e., H-pGlu-Gln-Ser-Leu-Gly-Asn-Gin-Trp-Ala-Arg-Gly-His-Phe-Met-NH.sub.2 or Gly-Asn-Gln-Trp-Ala-Arg-Gly-His-Phe-Met-NH.sub.2. Also disclosed are a vector and a cell containing such a DNA, a pharmaceutical composition which includes such a peptide, and a method of preparing such a peptide by recombinant technology.

REFERENCES:
Gispamer et al. "Parallel biassays of 27 bombesin-like peptides"Regul. Pept. (1988) 21(1-2) p. 1-11.
Corjay, et al; "Two Distinct Bombesin Receptor Subtypes are Expressed and Functional in Human Lung Carcinoma Cells;" J. Biol. Chem. 266:18771 (1991).
Giladi, et al; "Simple Luminometric Assay to Detect Phosphoinositol-Linked Receptor Expression in Xenopus Oocytes;" BioTechniques 10:744 (1991).
Wei, et al. "Pituitary Adenylate Cyclase Activating Polypeptide-Induced Desensitization on Growth Hormone Release From Rat Primary Pituitary Cells;" Biochem. and Biophys. Research Comm. 197:1396-1401 (1993).
Nagalla, et al; "Gastrin-Releasing Peptide (GRP) is not Mammalian Bombesin;" J. Biol. Chem. 267:6916-6922 (1992).
Spindel, et al; "Cloning of cDNAs Encoding Amphibian Bombesin: Evidence for the Relationship Between Bombesin and Gastrin-Releasing Peptide;" Proc. Natl. Acad. Sci. USA 87:9813 (1990).
Spindel, et al; "Bombesin-Like Peptides: of Ligands and Receptors;" Recent Progress in Hormone Research 48:365 (1993).

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