Bombesin receptor antagonists and uses thereof

Details Bombesin receptor antagonists and uses thereof Bombesin receptor antagonists and uses thereof

1993-12-17

1997-04-15

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 530326, 530327, A61K 3800, C07K 708

Patent

active

056209550

ABSTRACT:
Bombesin is an amphibian peptide that has a structure closely related to that of several mammalian peptides, including Gastrin Releasing Peptide (GRP) and Neuromedins B and C. Bombesin, GRP and related peptides exert their in vivo effects by binding to specific receptors present on cells of the gastrointestinal tract, the central nervous system, and tumors. The invention relates to novel bombesin derivatives which act as bombesin receptor antagonists by blocking the binding of bombesin, GRP or related peptides to cellular receptors. By blocking the binding of bombesin, GRP and related peptides to cellular receptors on cancer cells, these antagonists inhibit the growth of tumor cells that respond to the growth-promoting action of bombesin. These antagonists are expected to block the binding of bombesin, GRP or related peptides to similar receptors on cells in the gastrointestinal tract or the central nervous system. Thus, these antagonists have therapeutic use in the treatment or prevention of conditions mediated by bombesin, GRP or related peptides, including cancer and gastrointestinal disorders such as peptic ulcer, pancreatitis, and feeding disorders.

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