Bolus for releasing a biologically active substance into a liqui

Details Bolus for releasing a biologically active substance into a liqui Bolus for releasing a biologically active substance into a liqui

1986-06-03

1991-12-24

Rosenbaum, C. Fred

Surgery

Controlled release therapeutic device or system

Implanted dynamic device or system

424438, A23K 118

Patent

active

050748572

ABSTRACT:
A bolus for releasing a biologically active substance into a liquid environment according to this invention comprising an elongate core, at least one end of which is frustoconical and a liquid impervious casing at one end and open at the other disposed about the core, the bolus being so constructed that, in use, the casing is progressively shed as the core retreats, thereby releasing the active substance at a rate which varies over at least one time period, the casing being so structured as to retain its integrity without disintegrating in the absence of any support provided by the core.

REFERENCES:
patent: 2517513 (1950-08-01), Vaernet
patent: 4326524 (1982-04-01), Drake, Jr. et al.
patent: 4402693 (1983-09-01), Roseman et al.
patent: 4449982 (1984-05-01), Gould, III
patent: 4578263 (1986-03-01), Whitehead
patent: 4606354 (1986-08-01), Jacob
patent: 4623345 (1986-11-01), Laby
patent: 4642230 (1987-02-01), Whitehead et al.

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