Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1987-03-30
1990-06-19
Warren, Charles F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
4352535, 435887, C12R 1718, C12R 146
Patent
active
049353624
ABSTRACT:
A new antitumor antibiotic designated herein as BMY-28121 is produced by fermentation of Streptomyces albus strain K7331-113 (ATCC 39897). BMY-28121, which may be recovered from the fermentation broth in either its natural free hydroxy form (BMY-28121A) or methyl ether form (BMY-28121B), inhibits gram-positive bacteria and anaerobes and inhibits the growth of mammalian tumors such as P-388 leukemia, L-1210 leukemia and B16 melanoma.
REFERENCES:
Kouishi et al. (I), J. Antibiotics, 37(3) pp. 191-199 (1984).
Kouishi et al. (II). J. Antibiotics, 37(3) pp. 200-206 (1984).
Konishi Masataka
Miyaki Takeo
Tsunakawa Mitsuaki
Bristol-Myers Company
Marx Irene
Morse David M.
Warren Charles F.
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