BMP-3 propeptides and related methods

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S002600, C530S350000, C435S069100, C435S069700, C424S198100

Reexamination Certificate

active

07625867

ABSTRACT:
The present invention provides compositions and methods for promoting bone growth. The present invention also provides methods of screening compounds that modulate BMP-3A or BMP-3B activity. The compositions and methods provided herein are useful in modulating bone growth.

REFERENCES:
patent: 5637480 (1997-06-01), Celeste et al.
patent: 5808007 (1998-09-01), Lee et al.
patent: 5834179 (1998-11-01), Jones et al.
patent: 6004780 (1999-12-01), Soppet et al.
patent: 6071708 (2000-06-01), Jones et al.
patent: 6656708 (2003-12-01), Yu et al.
patent: 2003/0082233 (2003-05-01), Lyons et al.
patent: 2003/0144176 (2003-07-01), Olson et al.
patent: 2003/0224501 (2003-12-01), Young et al.
patent: 2005/0244867 (2005-11-01), Soppet et al.
patent: WO-94/03600 (1994-02-01), None
patent: WO-94/15965 (1994-07-01), None
patent: WO-94/26893 (1994-11-01), None
patent: WO-95/24474 (1995-09-01), None
patent: WO-96/39431 (1996-12-01), None
patent: WO-99/37320 (1999-07-01), None
patent: WO-00/43781 (2000-07-01), None
patent: WO-2001/922298 (2001-12-01), None
patent: WO 02/43759 (2002-06-01), None
Skolnick et al. From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech 18(1): 34-39, 2000.
Bork, A. Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res 10: 398-400, 2000.
Doerks et al. Protein annotation: detective work for function prediction. Trends in Genetics 14(6): 248-250, 1998.
Smith et al. The challenges of genome sequence annotation or “The devil is in the details”. Nature Biotech 15: 1222-1223, 1997.
Brenner, S.E. Errors in genome function. Trends in Genetics 15(4): 132-133, 1999.
Wells. J.A. Addivity of mutational effects in proteins. Biochemistry 29 (37): 8509-8517, 1990.
Ngo et al. Computational complexity, protein structure prediction, and the Levinthal paradox. The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Himo et al. Coordination of BMP-3b and cerberus is required for head formation of Xenopus embryos. Developmental Biology, 260, 138-157, available on line Jun. 4, 2003.
Graddis et al., Designing proteins that work using recombinant technologies, Curr. Pharm, Biotechnol., 3, 285, 2002.
Caricasole, et al., “Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours,” Oncogene, 16:95-103 (1998).
Chen, H., et al., “BMP10 is essential for maintaining cardiac growth during murine cardiogenesis,” Development, 131(9):2219-2231 (2004).
Clark, et al., “Human Stellar, NANOG and GDF3 Genes are Expressed in Pluripotent Cells and Map to Chromosome 12p13, a Hotspot for Teratocarcinoma,” Stem Cells, 22:169-179 (2004).
McPherron, et al., “GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines,” Journal of Biological Chemistry, 268(5): 3444-9 (1993).
Neuhaus, H., et al., “Heart specific expression of mouseBMP-10a novel member of the TGF-β superfamily,” Mechanisms of Development, 80:181-184 (1999).
Pashmforoush, M., et al., “Nkx2-5 Pathways and Congenital Heart Disease: Loss of Ventricular Myocyte Lineage Specification Leads to Progressive Cardiomyopathy and Complete Heart Block,” Cell, 117:373-386 (2004).
Jun et al., “Coordination of BMP-3b and cerebus is required for head formation of Xenopus embryos”, Developmental Biology, 260(1):138-157(2003).
Constam et al., “Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases”, The Journal of Cell Biology, 144(1):139-149(1999).
Nagaso et al., “Dual Specificity of Activin Type II Receptor ActRIIb in Dorso-Ventral Patterning During Zebrafish Embryogenesis”, Development Growth and Differentiation, 41(2)119-133(1999).
Takao et al., “Identification of Rat Bone Morphogenetic Protein-3b (BMP-3b), a New Member of BMP-3”, Biochemical and Biophysical Research Communications, 219(2)656-662(1996).
Daluiski et al., “Bone Morphogenetic Protein-3 is a Negative Regulatory of Bone Density”, Nature Genetics, 27(1):84-88(2001).
Hino et al., “Bone Morphogenetic Protein-3B (BMP-3B) Gene Expression is Correlated with Differentiation in Rat Calvarial Osteoblasts”, Biochemical and Biophysical Research Communications, 256(2):419-424(1999).
Faucheux et al., “Opposing Actions of BMP3 and TGF betal in Human Bone Marrow Stromal Cell Growth and Diffentiation”, Biochemical and Biophysical Research Communications, 241(3):787-793(1997).
Hino et al. “Bone Morphogenetic Protein-3 Family Members and Their Biological Functions,” Frontiers in Bioscience, 9:1520-1529(2004).
Teichmann, U., and Kessel, M., “Highly restricted BMP10 expression in the trabeculating myocardium of the chick embryo,” Dev Genes Evol., 214:96-98 (2004).
Wang, et al., “GDF-3 is an adipogenic cytokien under high fat dietary condition,” Biochemical and Biophysical Research Communications, 321:1024-1031(2004).
Witthuhn, et al., “Upregulation of Bone Morphogenetic Protein GDF-3/Vgr-2 Expression in Adipose Tissue of FABP4/aP2 Null Mice,” Cytokine, 14:129-135 (2001).

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