Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Patent
1998-01-09
1999-10-26
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
43525233, 4352542, 4352543, 4353201, 536 232, C12N 902
Patent
active
059726709
ABSTRACT:
The present invention relates to mutants of a blue multi-copper oxidase, comprising (a) a substitution of one or more amino acid residues with other amino acid residues, (b) an insertion of one or more amino acid residues and/or (c) a deletion of one or more amino acid residues, wherein the substitution, insertion or deletion is carried out at a position which is located no greater than 15 .ANG. from a Type I (T1) copper site. The present invention also relates to nucleic acid constructs comprising a nucleic acid sequence encoding the mutants of the present invention, host cells comprising the construct of the present invention, and methods for producing mutants of the present invention.
REFERENCES:
patent: 5480801 (1996-01-01), Wahleithner et al.
Germann, Ursula A. et al., "Characterization of Two Allelic Forms of Neurospora Crassa Laccase", 1988 by The American Society For Biochemistry And Molecular Biology, Inc., Jan. 15, vol. 263, No. 2, pp. 885-896.
Kojima Yasushi et al., "Cloning, Sequence Analysis, and Expression of Ligninolytic Phenoloxidase Genes of the White-rot Basidiomycete Coriolus", 1990 by The American Society of Biochemistry And Molecular Biology, vol. 265, No. 25, Sep. 5, pp. 15224-15230.
Askwith, Candice et al., "The FET3 Gene of S. Cerevisiae Encodes A Multicopper Oxidase Required For Ferrous Iron Uptake", Jan. 28, 1994, by Cell Press, vol. 76, pp. 403-410.
Berka Randy M.
Feng Xu
Wahleithner Jill Angela
Achutamurthy Ponnathapura
Lambiris Elias J.
Nashed Nashaat T.
Starnes Robert L.
Zelson Steve T.
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