Blood substitute containing modified hemoglobin

Details Blood substitute containing modified hemoglobin Blood substitute containing modified hemoglobin

1980-07-10

1981-11-17

Rosen, Sam

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424177, 260112R, A61K 3174, A61K 3700

Patent

active

043011446

ABSTRACT:
A novel modified hemoglobin was prepared. The hemoglobin is coupled with a polyalkylene glycol or its derivative, and the products are useful as a blood substitute. The oxygen-carrying capacity of this hemoglobin is nearly equal to that of a native hemoglobin, and the residence time in the circulation is satisfactorily long.

REFERENCES:
Sasakawa et al., Chem. Abst., vol. 77, (1972), p. 71989e.
Pace et al., Chem. Abst., vol. 79, (1973), p. 112553v.
Tam et al., Chem. Abst., vol. 85, (1976), p. 83209d.

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