Blood substitute comprising liposome-encapsulated hemoglobin

Details Blood substitute comprising liposome-encapsulated hemoglobin Blood substitute comprising liposome-encapsulated hemoglobin

1988-05-09

1990-03-27

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 436829, 514 6, 514832, 514833, A61K 3722, A61K 942, B01J 1302

Patent

active

049119290

ABSTRACT:
Sterile liposome-encapsulated hemoglobin having an oxygen carrying capacity of 20 vol/%, a half life of 15-20 hours as measured in mice, with the liposome made from chloroform, HSPC, cholesterol, negatively charged DMPG and alpha-tocopherol.

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patent: 4675310 (1987-06-01), Chapman et al.
patent: 4776991 (1988-10-01), Farmer et al.
Hunt et al., "Synthesis and Evaluation of a Prototypal Artificial Red Cel vol. 230, pp. 1165-1168, Dec. 6, 1985.
Gaber et al., "Encapsulation of Hemoglobin in Phospholipid Vesicles", vol. 153, #2, pp. 285-288, Mar. 1983.

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