Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1994-06-03
1997-12-30
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
604 4, A01N 102, A61M 3700
Patent
active
057028800
ABSTRACT:
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
REFERENCES:
patent: 3937821 (1976-02-01), Irikura et al.
patent: 3949098 (1976-04-01), Bangert
patent: 4923442 (1990-05-01), Segall et al.
patent: 5082831 (1992-01-01), Leaf et al.
patent: 5130230 (1992-07-01), Segall et al.
patent: 5171526 (1992-12-01), Wong et al.
patent: 5374624 (1994-12-01), Segel
Biochemistry, Worth Publishers, Inc., Lehninger pp. 705-713 (1982).
ATCC Catalogue of Bacteria & Bacteriophages p. 486, Medium 1590 (1992).
Belzer et al., "Combination Perfusion-Cold Storage for Optimum Cadaver Kidney Function and Utilization," Transplantation (1985) 39:118.
Kallerhoff et al., "Effects of Preservation Conditions and Temperature on Tissue Acidification in Canine Kidneys", Transplantation (1985) 39:485.
Ross et al., "72-HR Canine Kidney Preservation Without Continuous Perfusion," Transplantation (1976) 21:498.
Collins, G.M., "Hypothermic Kidney Storage," Transplantation Proceedings (1977) 9:1529.
Bishop et al., "Evaluation of Hypertonic Citrate Flushing Solution for Kidney Preservation Using the Isolated Perfused Rat Kidney," Transplantation (1978) 25:235.
Fisher et al., "Flush Solution 2, A New Concept for One-to-Three-Day Hypothermic Renal Storage Preservation," Transplantation (1985) 39:122.
Wall et al., "Simple Hypothermic Preservation of Transporting Human Livers Long Distances for Transplantation," Transplantation (1977) 23:210.
Sprung et al., "Effects of Acute Hyopthermia and .beta.-Adrenergic Receptor Blockade on Serum Potassium Concentration in Rats," Critical Care Medicine (1991) 29:1545.
Segall Judith M.
Segall Paul E.
Sternberg Hal
Waitz Harold D.
BioTime, Inc.
Bozicevic Karl
Saucier Sandra E.
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