Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1990-05-08
1992-07-14
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
604 49, 604 51, 604 52, 128897, 128898, 514 23, 514 56, 514 59, 424677, 424679, 424680, 424681, 424682, 424692, A61K 3170, A61K 5300, A61K 3314, A61K 31715
Patent
active
051302306
ABSTRACT:
A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water, electrolytes at physiological concentration, dextran 40 at a concentration sufficient for the blood substitute to achieve a colloidal suspension having a fluid osmotic pressure essentially equivalent to mammalian plasma, HEPES buffer at a physiological pH, dextrose, magnesium ion at a concentration of about 0.01M and potassium ion at a concentration greater than 10 mEq per liter sufficient to prevent or arrest cardiac fibrillation. In one embodiment the blood substitute is a multi-solution system wherein the solutions comprise differing levels of the above-indicated components and are administered sequentially to completely replace a subjects circulating blood.
REFERENCES:
Klebanoff et al. "Temporary Suspension of animation using total bodu perfusion and hypothermia" Cryobiology 6(2) 1969, pp. 121-125.
Haff et al. "Asanguineous Hypothermic Perfusion as a Means of Total Organism Preservation" J. of Surg. Res. 19, 1975, pp. 13-19.
Belzer et al. "Combination Perfusion-Cold Storage for Optimum Cadaver Kidney Function and Utilization" Transplantation 39(2) 1985 pp. 118-12.
Wall et al. "Simple Hypothermic Preservation for Transporting Human Livers Long Distances for Transplantation" Transplantation 23(3)19 pp. 210-221.
Gan et al. "Ice Cold Blood-Substituted Hamsters Revive" Federation Proceedings 44(3): 623 (1985).
Segall Paul E.
Sternberg Hal
Waitz Harold
Cryomedical Sciences Inc.
Fineman Elliott L.
Robinson Douglas W.
Witz Jean C.
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