Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-10-19
1990-04-24
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
514 6, 424101, C07K 1522, A61K 3714
Patent
active
049201948
ABSTRACT:
The invention relates to stroma-free blood substitutes, which are characterized in that fragments, prepared in a per se known manner, of sulfated glycosaminoglycans are covalently linked with hemoglobin to form products the oxygen binding property of which may be adjusted to be within the range of from 2.66 kPa (20 mmHg) to 10.66 kPa (80 mmHg), and preferably to within the range of from 4.79 kPa (36 mmHg) to 9.33 kPa (70 mmHg) by pre-determining the ratio of hemoglobin to glycosaminoglycan fragment, and to a process for preparing blood substitutes.
REFERENCES:
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4061736 (1977-12-01), Morris et al.
patent: 4401652 (1983-08-01), Simmonds et al.
patent: 4547490 (1985-10-01), Ecanow et al.
Chem. Abs., 85:15747c, "The Effect of Heparin on the Function and Structure of Adult Human Hemoglobin", Rucheaul, K. et al. (1975).
Bottrich Johannes G.
Feller Wolfgang
Macht Norbert
Perkins Susan M.
Schain Howard E.
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