Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1996-06-13
1998-11-10
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
424 932, 514836, 514937, A61B 5055
Patent
active
058339485
ABSTRACT:
The invention concerns NMR imaging contrast compositions comprising magnetically responsive species coupled to physiologically acceptable amphipatic organic substrate materials in the form of mixed micelles suspended or dispersed in a physiologically acceptable aqueous liquid carrier. The compositions are particularly useful for diagnostic investigations of the blood-pool. The invention also concerns the preparation of the mixed micelles, as well as of injectable compositions containing the mixed micelles as contrast agents for MRI purpose.
Once injected, the mixed micelles of the compositions behave as imaging contrast enhancers, e.g. they will improve the quality and resolution of the electronically processed images obtained during MRI examinations of the circulation and/or circulation targeted organs. The compositions are formulated to protect the particles of the contrast agents from early removal by the reticulo-endothelial (RES) system of the liver and the spleen, so that they will stay in the circulation for a time sufficient to properly image the blood vessels and to be transported to selected organs. MRI imaging of the circulation and of targeted organs can strongly assist in diagnosing possible ailments in human and animal patients.
REFERENCES:
patent: 4728575 (1988-03-01), Gamble et al.
patent: 5215680 (1993-06-01), D'Arrigo
patent: 5312617 (1994-05-01), Unger et al.
patent: 5387410 (1995-02-01), Bosworth et al.
patent: 5534241 (1996-07-01), Torchilin et al.
patent: 5567410 (1996-10-01), Torchilin et al.
Magnetic Resonance in Medicine, vol. 27, No. 1, Tilcock et al: "The Design of Liposomal Paramagnetic MR Agents: Effect of Vesicle Size Upon the Relaxivity of Surface-Incorporated Lipophilic Chelates," pp. 44-51.
J. Liposome Res. (1994), pp. 837-855, Schwendener: "Liposomes as carriers for paramagnetic gadolinium chelates as organ specific contrast agents for magnetic resonance imaging (MRI)".
Chemical Abstracts, vol. 110, No. 17, 24 Apr. 1989; Schwendener et al: "Small unilamellar lipsomes as magnetic resonance contrast agents loaded with paramagnetic manganese-, gadolinium-, and iron-DTPA-stearate complexes".
Hyacinthe Roland
Lamy Bernard
Tournier Herve
Bracco Research S.A.
Hollinden Gary E.
LandOfFree
Blood-pool imaging composition comprising micelles containing a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Blood-pool imaging composition comprising micelles containing a , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Blood-pool imaging composition comprising micelles containing a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1513713